Home LiteratureArticle Details
PMID: 8294493 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Bcl-2 and the regulation of programmed cell death.

The Journal of cell biology ·Vol. 124 ·No. 1-2 ·1994-01-00 ·Pages 1-6

Reed JC

Abstract

暂无摘要

Related Genes
bcl-2
MeSH Terms
Apoptosis Cell Compartmentation Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 18 Humans Proto-Oncogene Proteins/physiology Proto-Oncogene Proteins c-bcl-2 Translocation, Genetic
Chemicals
Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Reed J C
La Jolla Cancer Research Foundation, Cancer Research Center, California 92037.
References (64)
64 references, click to expand
  1. Structure-function analysis of the Bcl-2 oncoprotein. Addition of a heterologous transmembrane domain to portions of the Bcl-2 beta protein restores function as a regulator of cell survival.
    J Biol Chem. 1993 May 25;268(15):10920-6 PMID: 8496157
  2. Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line.
    Oncogene. 1993 Dec;8(12):3427-31 PMID: 8247547
  3. Bcl-2 expression in adult and embryonic non-haematopoietic tissues.
    J Pathol. 1993 Apr;169(4):431-7 PMID: 8501540
  4. bcl-2 inhibits death of central neural cells induced by multiple agents.
    Proc Natl Acad Sci U S A. 1993 May 15;90(10):4533-7 PMID: 8506295
  5. An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1.
    J Virol. 1993 Jul;67(7):4391-4 PMID: 8389936
  6. Effect of glucocorticosteroid treatment on intracellular calcium homeostasis in mouse lymphoma cells.
    Mol Endocrinol. 1993 May;7(5):686-93 PMID: 8316252
  7. Induction of cellular p53 activity by DNA-damaging agents and growth arrest.
    Mol Cell Biol. 1993 Jul;13(7):4242-50 PMID: 8321226
  8. Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene.
    Science. 1992 Oct 9;258(5080):302-4 PMID: 1411528
  9. Ultrastructural localization of bcl-2 protein.
    J Histochem Cytochem. 1992 Dec;40(12):1819-25 PMID: 1453000
  10. Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.
    Cancer Res. 1992 Dec 15;52(24):6940-4 PMID: 1458483
  11. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line.
    Blood. 1993 Jan 1;81(1):151-7 PMID: 8417786
  12. Stable expression of the calbindin-D28K complementary DNA interferes with the apoptotic pathway in lymphocytes.
    Mol Endocrinol. 1992 Nov;6(11):1843-8 PMID: 1336124
  13. Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells.
    Cell Growth Differ. 1993 Jan;4(1):41-7 PMID: 8424905
  14. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.
    Nature. 1993 Jan 28;361(6410):365-9 PMID: 8381212
  15. The protooncogene bcl-2 inhibits apoptosis in PC12 cells.
    J Neurochem. 1993 Mar;60(3):1183-6 PMID: 8436969
  16. Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene.
    Nature. 1993 Feb 25;361(6414):739-42 PMID: 8441470
  17. Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity.
    Cancer Res. 1993 Mar 15;53(6):1456-60 PMID: 8443823
  18. Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.
    J Biol Chem. 1993 Mar 25;268(9):6511-9 PMID: 8454620
  19. Expression of bcl-2 in fetal tissues suggests a role in morphogenesis.
    Am J Pathol. 1993 Mar;142(3):743-53 PMID: 7681256
  20. Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis.
    Cancer Res. 1993 Apr 15;53(8):1853-61 PMID: 8467505
  21. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.
    Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3516-20 PMID: 7682708
  22. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis.
    Cell. 1993 Apr 23;73(2):295-307 PMID: 8477446
  23. p53 is required for radiation-induced apoptosis in mouse thymocytes.
    Nature. 1993 Apr 29;362(6423):847-9 PMID: 8479522
  24. Thymocyte apoptosis induced by p53-dependent and independent pathways.
    Nature. 1993 Apr 29;362(6423):849-52 PMID: 8479523
  25. BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense.
    Proc Natl Acad Sci U S A. 1990 May;87(10):3660-4 PMID: 1692620
  26. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species.
    Science. 1993 Nov 19;262(5137):1274-7 PMID: 8235659
  27. Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy.
    Cell. 1982 Jan;28(1):71-81 PMID: 6978185
  28. Involvement of the bcl-2 gene in human follicular lymphoma.
    Science. 1985 Jun 21;228(4706):1440-3 PMID: 3874430
  29. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.
    Proc Natl Acad Sci U S A. 1986 Jul;83(14):5214-8 PMID: 3523487
  30. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation.
    Cell. 1986 Oct 10;47(1):19-28 PMID: 2875799
  31. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells.
    Nature. 1988 Sep 29;335(6189):440-2 PMID: 3262202
  32. bcl-2 and other genomic alterations in the prognosis of large-cell lymphoma.
    N Engl J Med. 1989 Apr 20;320(16):1047-54 PMID: 2648153
  33. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation.
    Cell. 1989 Apr 7;57(1):79-88 PMID: 2649247
  34. Induction of dependence on hematopoietic proteins for viability and receptor upregulation in differentiating myeloid leukemic cells.
    Blood. 1989 Aug 1;74(2):579-85 PMID: 2546628
  35. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis.
    Nature. 1990 Jan 4;343(6253):76-9 PMID: 1688645
  36. Membrane topology of the Bcl-2 proto-oncogenic protein demonstrated in vitro.
    J Biol Chem. 1990 Mar 25;265(9):4929-33 PMID: 2180952
  37. Antisense-mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides.
    Cancer Res. 1990 Oct 15;50(20):6565-70 PMID: 2208117
  38. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.
    Nature. 1990 Nov 22;348(6299):334-6 PMID: 2250705
  39. Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death.
    Cell. 1991 Jun 28;65(7):1107-15 PMID: 1648447
  40. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
    Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):6961-5 PMID: 1871110
  41. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.
    Oncogene. 1991 Oct;6(10):1915-22 PMID: 1923514
  42. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes.
    Cell. 1991 Nov 29;67(5):879-88 PMID: 1835668
  43. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship.
    Cell. 1991 Nov 29;67(5):889-99 PMID: 1959134
  44. Bcl-2/JH rearrangements in benign lymphoid tissues with follicular hyperplasia.
    Oncogene. 1991 Dec;6(12):2271-6 PMID: 1766674
  45. Induction of apoptosis in fibroblasts by c-myc protein.
    Cell. 1992 Apr 3;69(1):119-28 PMID: 1555236
  46. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.
    Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5408-12 PMID: 1608949
  47. Expression of bcl-2 in Burkitt's lymphoma cell lines: induction by latent Epstein-Barr virus genes.
    Blood. 1992 Jul 15;80(2):459-69 PMID: 1378321
  48. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas.
    Science. 1992 Jul 10;257(5067):212-4 PMID: 1378649
  49. Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice.
    Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7003-7 PMID: 1495993
  50. Detection of the t(14;18) at similar frequencies in hyperplastic lymphoid tissues from American and Japanese patients.
    Am J Pathol. 1992 Aug;141(2):291-9 PMID: 1497088
  51. Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells.
    Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7295-9 PMID: 1502141
  52. Molecular cloning and DNA sequence analysis of cDNA encoding chicken homologue of the Bcl-2 oncoprotein.
    Biochim Biophys Acta. 1992 Aug 17;1132(1):109-13 PMID: 1511008
  53. bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.
    Cancer Res. 1992 Oct 1;52(19):5407-11 PMID: 1394146
  54. Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents.
    J Exp Med. 1992 Oct 1;176(4):1043-51 PMID: 1402650
  55. Cooperative interaction between c-myc and bcl-2 proto-oncogenes.
    Nature. 1992 Oct 8;359(6395):554-6 PMID: 1406976
  56. Control of programmed cell death in normal and leukemic cells: new implications for therapy.
    Blood. 1993 Jul 1;82(1):15-21 PMID: 8324219
  57. bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways.
    Cancer Res. 1993 Jul 15;53(14):3321-6 PMID: 8324744
  58. Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2.
    J Immunol. 1993 Aug 15;151(4):1979-88 PMID: 8345191
  59. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.
    Cell. 1993 Aug 27;74(4):609-19 PMID: 8358790
  60. Investigations of antisense oligonucleotides targeted against bcl-2 RNAs.
    Antisense Res Dev. 1993 Summer;3(2):157-69 PMID: 8400801
  61. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.
    Cancer Res. 1993 Oct 1;53(19):4701-14 PMID: 8402648
  62. Bcl-2 functions in an antioxidant pathway to prevent apoptosis.
    Cell. 1993 Oct 22;75(2):241-51 PMID: 7503812
  63. Bcl-2 associates with the ras-related protein R-ras p23.
    Nature. 1993 Nov 18;366(6452):274-5 PMID: 8232588
  64. High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy.
    Blood. 1993 Jun 1;81(11):3091-6 PMID: 7684624
Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.124.1.1
Published
1994-01-00
Pages
1-6
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2119888
Subset
IM
Grants
NCI NIH HHS · CA-47956 · United States
NCI NIH HHS · CA-60181 · United States
External Links
PubMed source DOI: 10.1083/jcb.124.1.1 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2