Enzyme-activated antagonists of the strychnine-insensitive glycine/NMDA receptor.

Journal of medicinal chemistry ·Vol. 37 ·No. 3 ·1994-02-04 ·Pages 334-6

Salituro FG, Tomlinson RC, Baron BM, Palfreyman MG, McDonald IA, Schmidt W, Wu HQ, Guidetti P, Schwarcz R

Abstract

暂无摘要

MeSH Terms

Animals Binding Sites Binding, Competitive Cerebral Cortex/enzymology Chromatography, High Pressure Liquid Cyclization Glycine/antagonists & inhibitors,metabolism Kinetics Kynurenine/analogs & derivatives,metabolism Lyases Male Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors,metabolism Strychnine/pharmacology Transaminases/metabolism

Chemicals

Receptors, N-Methyl-D-Aspartate Kynurenine 4-chlorokynurenine Transaminases glutamine - phenylpyruvate transaminase kynurenine-oxoglutarate transaminase Lyases Strychnine Glycine

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Salituro F G

Marion Merrell Dow Research Institute, Cincinnati, Ohio 45215.

Tomlinson R C

Baron B M

Palfreyman M G

McDonald I A

Schmidt W

Wu H Q

Guidetti P

Schwarcz R

Article Info

Journal

Journal of medicinal chemistry

Abbr.

J Med Chem

ISSN

0022-2623

DOI

10.1021/jm00029a003

Published

1994-02-04

Pages

334-6

Language

English

Region

United States

NLM ID

9716531

Subset

External Links

PubMed source DOI: 10.1021/jm00029a003 View journal details

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Enzyme-activated antagonists of the strychnine-insensitive glycine/NMDA receptor.

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