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PMID: 8325367 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme.

FEBS letters ·Vol. 326 ·No. 1-3 ·1993-07-12 ·Pages 171-6

Miura N, Wanaka A, Tohyama M, Tanaka K

Abstract

We have isolated a novel mouse gene, MFH-1 (mesenchyme fork head 1) that is related to the Drosophila fork head and rat HNF3 genes. MFH-1 encodes a distinct fork head domain that is classified into a distinct subfamily. A recombinant MFH-1 protein could bind to the HNF3 binding site. MFH-1 is expressed temporally in developing embryos, first in the non-notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head, and limbs. Our results suggest that MFH-1 might be involved in the formation of special mesenchymal tissues.

Related Genes

MFH-1

MeSH Terms

Amino Acid Sequence Animals Brain/metabolism DNA-Binding Proteins/chemistry,genetics Drosophila Embryo, Mammalian/metabolism Embryo, Nonmammalian Embryonic and Fetal Development Forkhead Transcription Factors Gene Expression Hepatocyte Nuclear Factor 3-alpha Hepatocyte Nuclear Factor 3-beta Hepatocyte Nuclear Factor 3-gamma Mesoderm/metabolism Mice Molecular Sequence Data Nuclear Proteins/chemistry,genetics Polymerase Chain Reaction RNA, Messenger/analysis Rats Sequence Homology Transcription Factors/chemistry,genetics

Chemicals

DNA-Binding Proteins Forkhead Transcription Factors Foxa1 protein, mouse Foxa1 protein, rat Foxa2 protein, mouse Foxa2 protein, rat Foxa3 protein, mouse Foxa3 protein, rat Hepatocyte Nuclear Factor 3-alpha Nuclear Proteins RNA, Messenger Transcription Factors mesenchyme fork head 1 protein Hepatocyte Nuclear Factor 3-gamma Hepatocyte Nuclear Factor 3-beta

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Miura N

Institute for Molecular and Cellular Biology, Osaka University, Yamada-Oka, Japan.

Wanaka A

Tohyama M

Tanaka K

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(93)81785-x

Published

1993-07-12

Pages

171-6

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(93)81785-x View journal details

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MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme.

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