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PMID: 8328793 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Susceptibilities of serial Cryptococcus neoformans isolates from patients with recurrent cryptococcal meningitis to amphotericin B and fluconazole.

Antimicrobial agents and chemotherapy ·Vol. 37 ·No. 6 ·1993-06-00 ·Pages 1383-6

Casadevall A, Spitzer ED, Webb D, Rinaldi MG

Abstract

Amphotericin B and fluconazole susceptibilities of 13 Cryptococcus neoformans isolates from five patients with recurrent cryptococcal meningitis were determined. For each patient, serial isolates showed no increase in antibiotic resistance relative to the initial isolate. For these patients, recurrent disease was not due to drug resistance but may reflect changes in immune function and/or poor compliance.

MeSH Terms
AIDS-Related Opportunistic Infections/drug therapy Amphotericin B/pharmacology Cryptococcus neoformans/drug effects Drug Resistance, Microbial Fluconazole/pharmacology Humans Meningitis, Cryptococcal/complications,drug therapy,microbiology Microbial Sensitivity Tests
Chemicals
Amphotericin B Fluconazole
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Casadevall A
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.
Spitzer E D
Webb D
Rinaldi M G
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24 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.37.6.1383
Published
1993-06-00
Pages
1383-6
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC187974
Subset
IM
Grants
NIAID NIH HHS · AI32430 · United States
External Links
PubMed source DOI: 10.1128/AAC.37.6.1383 PMC Full Text View journal details
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