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PMID: 832895 Published · ppublish English Journal Article

Immunogenic activity of a ribosomal fraction obtained from Pasteurella multocida.

Infection and immunity ·Vol. 15 ·No. 1 ·1977-01-00 ·Pages 1-6

Baba T

Abstract

The cells of P. multocida strain P-1059 were destroyed with the French pressure cell; the ribosomal fraction proven to be homogeneous by analytical ultracentrifugation was obtained from the product by centrifugal fractionation, zonal electrophoresis, and Sephadex G-200 gel filtration. The ribosomal fraction exhibited intense protective antigenicity in mice and chickens, but the lipopolysaccharide (endotoxin) and the other bacterial cell fraction obtained in this experiment did not. Sodium deoxycholate treatment of the ribosomal fraction resulted in only a 13% loss in immunological activity, and ribonuclease treatment caused a 60% loss of activity.

MeSH Terms
Animals Antigens Chickens Cholera/prevention & control Deoxycholic Acid/metabolism Male Mice Pasteurella/immunology Pasteurella Infections/prevention & control RNA, Ribosomal/immunology Ribosomal Proteins/immunology Ribosomes/immunology Subcellular Fractions
Chemicals
Antigens RNA, Ribosomal Ribosomal Proteins Deoxycholic Acid
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Baba T
References (16)
16 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.15.1.1-6.1977
Published
1977-01-00
Pages
1-6
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC421321
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.15.1.1-6.1977 PMC Full Text View journal details
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