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PMID: 8356453 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genotypic and phenotypic characterization of HIV-1 patients with primary infection.

Science (New York, N.Y.) ·Vol. 261 ·No. 5125 ·1993-08-27 ·Pages 1179-81

Zhu T, Mo H, Wang N, Nam DS, Cao Y, Koup RA, Ho DD

Abstract

Better characterization of human immunodeficiency virus-type 1 (HIV-1) in patients with primary infection has important implications for the development of an acquired immunodeficiency syndrome (AIDS) vaccine because vaccine strategies should target viral isolates with the properties of transmitted viruses. In five HIV-1 seroconverters, the viral phenotype was found to be uniformly macrophage-tropic and non-syncytium-inducing. Furthermore, the viruses were genotypically homogeneous within each patient, but a common signature sequence was not discernible among transmitted viruses. In the two cases where the sexual partners were also studied, the sequences of the transmitted viruses matched best with minor variants in the blood of the transmitters. There was also a stronger pressure to conserve sequences in gp120 than in gp41, nef, and p17, suggesting that a selective mechanism is involved in transmission.

MeSH Terms
Amino Acid Sequence Base Sequence Cell Line Female Gene Products, gag/chemistry,genetics Genes, Viral Genotype Giant Cells/physiology HIV Antigens/chemistry,genetics HIV Envelope Protein gp120/chemistry,genetics HIV Envelope Protein gp41/chemistry,genetics HIV Infections/microbiology,transmission HIV Seropositivity/microbiology HIV-1/chemistry,genetics,physiology Humans Macrophages Male Molecular Sequence Data Phenotype Sequence Alignment Sexual Partners Viral Proteins Virus Replication gag Gene Products, Human Immunodeficiency Virus
Chemicals
Gene Products, gag HIV Antigens HIV Envelope Protein gp120 HIV Envelope Protein gp41 Viral Proteins gag Gene Products, Human Immunodeficiency Virus p17 protein, Human Immunodeficiency Virus Type 1
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Zhu T
Aaron Diamond AIDS Research Center, New York University School of Medicine, NY 10016.
Mo H
Wang N
Nam D S
Cao Y
Koup R A
Ho D D
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.8356453
Published
1993-08-27
Pages
1179-81
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NIAID NIH HHS · AI24030 · United States
NIAID NIH HHS · AI25541 · United States
NIAID NIH HHS · AI27742 · United States
Databases
GENBANK
L21224, L21225, L21226, L21227, L21228, L21229, L21230, L21231, L21232, L21233, L21234, L21235, L21236, L21237, L21238, L21239, L21240, L21241, L21242, L21243, L21244, L21245, L21246, L21247, L21248, L21249, L21250, L21251, L21252, L21253
External Links
PubMed source DOI: 10.1126/science.8356453 View journal details
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