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PMID: 836997 Published · ppublish English Journal Article

Thyroid hormone-dependent interconversion of myocardial alpha- and beta-adrenoceptors in the rat.

British journal of pharmacology ·Vol. 59 ·No. 1 ·1977-01-00 ·Pages 177-89

Kunos G

Abstract

1 The effects of thyroid state on the properties of adrenoceptors mediating inotropic and chronotropic responses of the rat heart were assessed on the basis of the relative potencies of alpha- and beta-adrenoceptor agonists, the effects of alpha- and beta-adrenoceptor antagonists and the tissue uptake of [3H]-phenoxybenzamine ([3H]-PB). 2 In isolated, electrically driven left atria the ratio of the inotropic potencies of isoprenaline and phenylephrine and the inhibitory potency of propranolol (40nM-4 muM) were significantly reduced after thyroidectomy and were moderately increased after thyroxine treatment of control rats. 3 Block of inotropic responses to noradrenaline and to phenylephrine by PB (7.3 nM-7.3 muM) and the tissue uptake of [3H]-PB were significantly greater in preparations from thyroidectomized than in those from control or from thyroxine treated rats. alpha-Adrenoceptor inhibition by phentolamine (0.26-2.6 muM) also increased after thyroidectomy, and phentolamine effectively protected alpha-adrenoceptors from block by and binding of [3H]-PB. 4 The beta1-receptor antagonist H 93/26 (0.1 muM) significantly potentiated alpha-adrenoceptor blockade by PB in hypothyroid but not in control preparations. 5 In spontaneously beating right atria the chronotropic potency of agonists and the effects of antagonists were altered in the same way as were inotropic responses and the slope of the agonist concentration-response curves were significantly reduced after thyroidectomy. Effects of agonists and antagonists were not significantly influenced by thyroxine treatment. 6 Changes in the effects and tissue uptake of sympathomimetic drugs observed after thyroidectomy were reversed to or beyond control levels by thyroid hormone treatment of thyroidectomized animals. 7 The results presented are interpreted as indicating a thyroid hormone-dependent interconversion of myocardial alpha- and beta-adrenoceptors. It is suggested that this interconversion is similar to that observed earlier in frog hearts at different temperatures, and that both effects may reflect an allosteric transition between two forms of a single basic structure.

MeSH Terms
Animals Atrial Function Body Weight Calcium/pharmacology Dose-Response Relationship, Drug Heart/drug effects Heart Atria/drug effects Heart Rate/drug effects Isoproterenol/pharmacology Kinetics Male Myocardial Contraction/drug effects Myocardium/metabolism Phenoxybenzamine/metabolism Phentolamine/pharmacology Phenylephrine/pharmacology Propranolol/pharmacology Rats Receptors, Adrenergic/drug effects,metabolism Thyroidectomy Thyroxine/blood,pharmacology Triiodothyronine/pharmacology
Chemicals
Receptors, Adrenergic Triiodothyronine Phenoxybenzamine Phenylephrine Propranolol Isoproterenol Thyroxine Calcium Phentolamine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kunos G
References (49)
49 references, click to expand
  1. Dissociation of cardiac inotropic and adenylate cyclast activating adrenoceptors.
    Br J Pharmacol. 1974 Jun;51(2):253-7 PMID: 4375524
  2. Dissociation of alpha adrenergic receptor protection from inhibition of H-phenoxybenlamine binding in vascular tissue.
    J Pharmacol Exp Ther. 1973 Jul;186(1):100-8 PMID: 4146698
  3. Decreased myocardial adenyl cyclase activity in hypothyroidism.
    J Clin Invest. 1969 Dec;48(12):2244-50 PMID: 4311237
  4. Analysis of the adrenergic receptors of pacemaker and myocardial cells.
    Eur J Pharmacol. 1972 Jan;17(1):1-7 PMID: 4401431
  5. A comparison between the negative inotropic action of various antiarrhythmic drugs and their influence on calcium movements in heart muscle.
    J Pharm Pharmacol. 1972 May;24(5):367-73 PMID: 4403805
  6. Modulator theory of adrenergic receptor mechanism: vessels of the dog hindlimb.
    Am J Physiol. 1970 Mar;218(3):869-75 PMID: 4391825
  7. Combinations of alpha and beta adrenergic blockers in isolated guinea-pig atria.
    J Pharmacol Exp Ther. 1969 Dec;170(2):262-71 PMID: 4391006
  8. Temperature-induced interconversion of alpha-and beta-adrenoceptors in the frog heart.
    J Physiol. 1976 Mar;256(1):23-40 PMID: 1084421
  9. Effects of propranolol and a new 'cardioselective' beta-blocker, H 93-26, on responses of isolated rat atria to isoprenaline and noradrenaline.
    Eur J Pharmacol. 1973 Nov;24(2):194-204 PMID: 4148794
  10. Studies of fetal mouse hearts in organ culture: influence of prolonged exposure to triiodothyronine on cardiac responsiveness to isoproterenol, glucagon, theophylline, acetylcholine and dibutyryl cyclic 3',5'-adenosine monophosphate.
    J Pharmacol Exp Ther. 1974 Aug;190(2):272-9 PMID: 4375178
  11. Myocardial alpha adrenergic receptors and their role in the production of a positive inotropic effect by sympathomimetic agents.
    J Pharmacol Exp Ther. 1968 Jan;159(1):82-90 PMID: 4384517
  12. Evidence favouring the existence of a single adrenergic receptor.
    Nature. 1968 Mar 16;217(5133):1077-8 PMID: 4384499
  13. Interactions between sympathomimetic amines and blocking agents on the rat ventricle strip.
    Arch Int Pharmacodyn Ther. 1966 Apr;160(2):379-89 PMID: 4380923
  14. Effect of chlorpromazine, dibenamine and phenoxybenzamine on the contractile response of taenia coli to potassium, acetylcholine, angiotensin and barium.
    J Pharmacol Exp Ther. 1968 Mar;160(1):106-11 PMID: 4384272
  15. Interchange of adenyl and guanyl cyclases as an explanation for transformation of Beta- to alpha-adrenergic responses in the rat atrium.
    Nature. 1975 Jul 31;256(5516):421-4 PMID: 238135
  16. Beta2-adrenergic stimulation of thyroid hormone secretion.
    Endocrinology. 1975 Aug;97(2):332-6 PMID: 239845
  17. Metabolic inhibition and adrenoceptor interconversion.
    Arch Int Pharmacodyn Ther. 1975 Nov;218(1):4-10 PMID: 2120
  18. Cellular lesions induced by isoproterenol in frog heart sensitized by increased environmental temperature.
    J Mol Cell Cardiol. 1973 Aug;5(4):313-7 PMID: 4542764
  19. Lowered chronotropic sensitivity of rat and frog hearts to sympathomimetic amines following cold acclimation.
    Acta Physiol Scand. 1974 Jan;90(1):260-6 PMID: 4544401
  20. Evidence for the existence of alpha adrenergic receptor in isolated rat atria.
    Jpn J Pharmacol. 1972 Apr;22(2):227-33 PMID: 4538414
  21. Modulation by thyroid hormones of cytoplasmic estrogen receptor concentrations in reproductive tissues of the rat.
    Endocrinology. 1975 Jul;97(1):59-67 PMID: 166834
  22. Effect of the thyroid state on the enzymatic characteristics of cardiac myosin. A difference in behavior of rat and rabbit cardiac myosin.
    Circ Res. 1975 Jan;36(1):208-15 PMID: 123179
  23. Temperature-dependent sensitivity of adrenoreceptors in the toad's heart.
    Acta Pharmacol Toxicol (Copenh). 1973;33(4):273-9 PMID: 4800673
  24. Effects of throxine on calorigenic response of the newborn rat to norepinephrine.
    Am J Physiol. 1973 Apr;224(4):979-84 PMID: 4698815
  25. Enhancement of the alpha adrenergic response in aorta from hypothyroid rabbits.
    Life Sci I. 1972 Jun 15;11(12):595-604 PMID: 4656873
  26. Effect of hypothyroid status on myocardial responses to sympathomimetic drugs.
    Jpn J Pharmacol. 1971 Dec;21(6):819-25 PMID: 5316867
  27. Thyroid-catecholamine interrelations.
    Annu Rev Med. 1966;17:123-32 PMID: 5327154
  28. Adrenergic receptors in heart muscle: relations among factors influencing the sensitivity of the cat papillary muscle to catecholamines.
    J Pharmacol Exp Ther. 1970 Jun;173(2):383-98 PMID: 5434021
  29. Temperature modulation of alpha- and beta-adrenoceptors in the isolated frog heart.
    Br J Pharmacol. 1970 Feb;38(2):394-8 PMID: 5417862
  30. Influence of the thyroid state on the intrinsic contractile properties and energy stores of the myocardium.
    J Clin Invest. 1967 Oct;46(10):1669-82 PMID: 6061742
  31. Interactions of sympathomimetic drugs, propranolol and phentolamine, on atrial refractory period and contractility.
    Br J Pharmacol Chemother. 1967 Aug;30(3):603-11 PMID: 6058154
  32. On the application of "a plausible model" of allosteric proteins to the receptor for acetylcholine.
    J Theor Biol. 1967 Aug;16(2):306-20 PMID: 6048545
  33. Cardiovascular and myocardial metabolic effects of infusions of phenylephrine.
    J Pharmacol Exp Ther. 1967 May;156(2):325-30 PMID: 6026262
  34. The effect of epinephrine on adenosine 3', 5'-phosphate levels in the isolated perfused rat heart.
    Mol Pharmacol. 1965 Sep;1(2):168-77 PMID: 5835697
  35. DETERMINATION OF THYROXINE UTILIZING THE PROPERTY OF PROTEIN-BINDING.
    J Clin Endocrinol Metab. 1964 Feb;24:187-96 PMID: 14123843
  36. Adenyl cyclase. III. The effect of catecholamines and choline esters on the formation of adenosine 3',5'-phosphate by preparations from cardiac muscle and liver.
    J Biol Chem. 1962 Apr;237:1233-8 PMID: 14477266
  37. EFFECT OF THYROID HORMONES ON VASCULAR RESPONSE.
    J Lab Clin Med. 1964 Sep;64:433-41 PMID: 14215459
  38. ADRENAL MEDULLARY AND THYROID RELATIONSHIPS.
    Physiol Rev. 1964 Apr;44:161-85 PMID: 14152904
  39. Blockade of responses of isolated myocardium to epinephrine.
    J Pharmacol Exp Ther. 1961 Aug;133:186-91 PMID: 13728789
  40. Relationship between thyroid function and cardiotoxic properties of isoproterenol.
    Endocrinology. 1959 Aug;65(2):208-15 PMID: 13672143
  41. Use of radioactive iodine in the treatment of angina pectoris.
    Am J Cardiol. 1958 Jun;1(6):671-81 PMID: 13533290
  42. A modification of receptor theory.
    Br J Pharmacol Chemother. 1956 Dec;11(4):379-93 PMID: 13383117
  43. Reactions of dibenamine and some congeners with substances of biological interest in relation to the mechanism of adrenergic blockade.
    J Pharmacol Exp Ther. 1954 Nov;112(3):274-90 PMID: 13212639
  44. Blockade of epinephrine-induced cardio-acceleration in the frog.
    Am J Physiol. 1950 Dec;163(3):484-504 PMID: 14799624
  45. Triiodothyronine and thyroxine: induction of mitosis in adult frogs.
    Experientia. 1973 Oct 15;29(10):1291-2 PMID: 4543320
  46. The effect of altered thyroid state on atrial intracellular potentials.
    J Physiol. 1970 Apr;207(2):357-69 PMID: 5499024
  47. Transformation of adrenergic receptors in the myocardium.
    Nat New Biol. 1973 Jan 24;241(108):119-20 PMID: 4512453
  48. Effects of thyroid state on adrenoceptor properties.
    Nature. 1974 Aug 30;250(5469):779-81 PMID: 4153342
  49. Temperature-dependent interconversion of histamine H1 and H2 receptors in guinea pig ileum.
    Nature. 1974 Nov 1;252(5478):54-5 PMID: 4154408
Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1977.tb06992.x
Published
1977-01-00
Pages
177-89
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1667708
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1977.tb06992.x PMC Full Text View journal details
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