Central actions of histamine: microelectrophoretic studies.

Brain research ·Vol. 122 ·No. 2 ·1977-02-18 ·Pages 269-79

Haas HL, Wolf P

Abstract

Responses of neurones in different regions of the rat and cat brain to micro-electrophoretically applied histamine and some related substances including antagonists are reported. Histamine excites most neurones in the hypothalamus but depresses the vast majority of neurones in other structures. Depressant actions of histamine and some inhibitions in the cortex and hippocampus of the rat are antagonized by metiamide, an H2-receptor antagonist. The results lend strong support to the idea of histaminergic transmission in the mammalian brain.

MeSH Terms

Action Potentials/drug effects Animals Betazole/pharmacology Brain/drug effects Cats Cerebral Cortex/drug effects Depression, Chemical Hippocampus/drug effects Histamine/pharmacology Hypothalamus/drug effects Mesencephalon/drug effects Methylhistamines/pharmacology Metiamide/pharmacology Rats Reaction Time Supraoptic Nucleus/drug effects Synapses/drug effects Time Factors gamma-Aminobutyric Acid/pharmacology

Chemicals

Methylhistamines Betazole Metiamide gamma-Aminobutyric Acid Histamine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Haas H L

Wolf P

Article Info

Journal

Brain research

Abbr.

Brain Res

ISSN

0006-8993

DOI

10.1016/0006-8993(77)90294-3

Published

1977-02-18

Pages

269-79

Language

English

Region

Netherlands

NLM ID

0045503

Subset

External Links

PubMed source DOI: 10.1016/0006-8993(77)90294-3 View journal details

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