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PMID: 8375661 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Pattern of nucleotide substitutions in growth hormone-prolactin gene family: a paradigm for evolution by gene duplication.

Genetics ·Vol. 134 ·No. 4 ·1993-08-00 ·Pages 1271-6

Ohta T

Abstract

The growth hormone-prolactin gene family in mammals is an interesting example of evolution by gene duplication. Divergence among members of duplicated gene families and among species was examined by using reported gene sequences of growth hormone, prolactin and their receptors. Sequence divergence among species was found to show a general tendency in which a generation-time effect is pronounced for synonymous substitutions but not so for nonsynonymous substitutions. Divergence among duplicated genes is characterized by the relatively high rate of nonsynonymous substitutions, i.e., the rate is close to that of synonymous ones. In view of the stage- and tissue-specific expression of duplicated genes, some of the amino acid substitutions among duplicated genes is likely to be caused by positive Darwinian selection.

MeSH Terms
Amino Acid Sequence Animals Biological Evolution Genetic Variation Growth Hormone/genetics Humans Models, Genetic Molecular Sequence Data Multigene Family Prolactin/genetics
Chemicals
Prolactin Growth Hormone
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ohta T
National Institute of Genetics, Mishima, Japan.
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30 references, click to expand
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/134.4.1271
Published
1993-08-00
Pages
1271-6
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1205594
Subset
IM
External Links
PubMed source DOI: 10.1093/genetics/134.4.1271 PMC Full Text View journal details
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