Home LiteratureArticle Details

PMID: 8379000 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Mutagenesis by 8-oxoguanine: an enemy within.

Trends in genetics : TIG ·Vol. 9 ·No. 7 ·1993-07-00 ·Pages 246-9

Grollman AP, Moriya M

Abstract

The presence of reactive oxygen species in cells ensures that the oxidatively damaged base 8-oxoguanine will be generated at high frequency in the DNA of all living organisms. DNA damage threatens genomic integrity: enzymes have evolved that protect prokaryotes and eukaryotes from the mutagenic effect of this ubiquitous lesion.

Related Genes

mut

MeSH Terms

DNA Damage DNA Glycosylases DNA Repair/physiology DNA-Formamidopyrimidine Glycosylase Escherichia coli/genetics Escherichia coli Proteins Guanine/analogs & derivatives,physiology Mutagenesis N-Glycosyl Hydrolases/physiology Reactive Oxygen Species

Chemicals

Escherichia coli Proteins Reactive Oxygen Species 8-hydroxyguanine Guanine DNA Glycosylases N-Glycosyl Hydrolases mutY adenine glycosylase DNA-Formamidopyrimidine Glycosylase DNA-formamidopyrimidine glycosylase, E coli

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Grollman A P

Department of Pharmacological Sciences, State University of New York, Stony Brook 11794-8651.

Moriya M

Article Info

Journal

Trends in genetics : TIG

Abbr.

Trends Genet

ISSN

0168-9525

DOI

10.1016/0168-9525(93)90089-z

Published

1993-07-00

Pages

246-9

Language

English

Region

England

NLM ID

8507085

Subset

Grants

NCI NIH HHS · CA17395 · United States

NCI NIH HHS · CA47995 · United States

External Links

PubMed source DOI: 10.1016/0168-9525(93)90089-z View journal details

Analysis Services

Mutagenesis by 8-oxoguanine: an enemy within.

Contact

WeChat Official Account