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PMID: 8386704 Published · ppublish English Journal Article

Kupffer cell elimination enhances development of liver schizonts of Plasmodium berghei in rats.

Infection and immunity ·Vol. 61 ·No. 5 ·1993-05-00 ·Pages 1936-9

Vreden SG, Sauerwein RW, Verhave JP, Van Rooijen N, Meuwissen JH, Van Den Broek MF

Abstract

We investigated the development of exoerythrocytic forms (EEF) of Plasmodium berghei in livers of normal and macrophage-depleted Brown Norway rats. Macrophages were depleted by use of liposome-encapsulated dichloromethylene diphosphonate. Upon inoculation of sporozoites, macrophage-depleted rats had significantly larger numbers of EEF than untreated rats. We also investigated the effect of macrophage impairment by silica treatment on the development of EEF and confirmed that silica induces a significant reduction of EEF development. Intravenous administration of silica induced high levels of interleukin-6 in plasma within a few hours. The seemingly contradictory results for EEF development may be explained by our previous observation that interleukin-6 strongly inhibits sporozoite penetration and EEF development in vivo. We conclude that in experimental infections with sporozoites, Kupffer cells inhibit rather than enhance EEF development.

MeSH Terms
Animals Interleukin-6/metabolism Kupffer Cells/parasitology Liposomes Liver/parasitology Macrophages/immunology Malaria/immunology,parasitology Male Plasmodium berghei/growth & development Rats Rats, Inbred BN Silicon Dioxide/pharmacology
Chemicals
Interleukin-6 Liposomes Silicon Dioxide
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Vreden S G
Department of Medical Microbiology, Nijmegen University Hospital, Nijmegen, The Netherlands.
Sauerwein R W
Verhave J P
Van Rooijen N
Meuwissen J H
Van Den Broek M F
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.61.5.1936-1939.1993
Published
1993-05-00
Pages
1936-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC280786
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.61.5.1936-1939.1993 PMC Full Text View journal details
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