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PMID: 8387228 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Protein-induced bending as a transcriptional switch.

Science (New York, N.Y.) ·Vol. 260 ·No. 5109 ·1993-05-07 ·Pages 805-7

Pérez-Martín J, Espinosa M

Abstract

The question of whether protein-induced DNA bending can act as a switch factor when placed upstream of an array of promoters located in tandem was investigated in vivo. The catabolite activating protein binding site of the fur operon was replaced by the binding site of the RepA repressor protein, which is able to bend DNA immediately after binding. Appropriately phased induced bending could act as a transcriptional switch factor in vivo.

Related Genes
fur
MeSH Terms
Bacterial Proteins/genetics,metabolism Base Sequence Cyclic AMP Receptor Protein/metabolism DNA Helicases DNA, Bacterial/chemistry,genetics,metabolism DNA-Binding Proteins/metabolism DNA-Directed RNA Polymerases/metabolism Escherichia coli/genetics Gene Expression Regulation, Bacterial Molecular Sequence Data Nucleic Acid Conformation Operon Promoter Regions, Genetic Proteins Repressor Proteins/genetics Trans-Activators Transcription, Genetic
Chemicals
Bacterial Proteins Cyclic AMP Receptor Protein DNA, Bacterial DNA-Binding Proteins Proteins Repressor Proteins Trans-Activators ferric uptake regulating proteins, bacterial replication initiator protein DNA-Directed RNA Polymerases DNA Helicases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pérez-Martín J
Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Cientifícas, Madrid, Spain.
Espinosa M
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.8387228
Published
1993-05-07
Pages
805-7
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.8387228 View journal details
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