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PMID: 8406877 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Plasmodium falciparum varies in its ability to induce tumor necrosis factor.

Infection and immunity ·Vol. 61 ·No. 11 ·1993-11-00 ·Pages 4772-6

Allan RJ, Rowe A, Kwiatkowski D

Abstract

Tumor necrosis factor (TNF) has a variety of protective and pathological actions in human malaria. We report that different laboratory lines of Plasmodium falciparum which were derived from a single wild isolate (IT 4/25/5) varied widely in their ability to stimulate TNF production by human mononuclear cells. In the cloned line R29 we observed that subcultures selected for high rosetting frequency gave significantly higher levels of TNF stimulation than subcultures with low rosetting frequency, indicating that TNF induction can vary within populations that have originated from a single genotype. These results raise the possibility that the clinical severity of malaria is partly determined by the TNF-inducing activity of the infecting strain of parasite.

MeSH Terms
Animals Humans Plasmodium falciparum/pathogenicity Rosette Formation Tumor Necrosis Factor-alpha/biosynthesis
Chemicals
Tumor Necrosis Factor-alpha
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Allan R J
Molecular Infectious Disease Group, John Radcliffe Hospital, Headington, Oxford, United Kingdom.
Rowe A
Kwiatkowski D
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.61.11.4772-4776.1993
Published
1993-11-00
Pages
4772-6
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC281233
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.61.11.4772-4776.1993 PMC Full Text View journal details
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