Rat CINC (cytokine-induced neutrophil chemoattractant) is the homolog of the human GRO proteins but is encoded by a single gene.

Biochemical and biophysical research communications ·Vol. 190 ·No. 1 ·1993-01-15 ·Pages 104-10

Zagorski J, DeLarco JE

Abstract

Human GRO and rat CINC proteins are members of the pro-inflammatory "chemokine" superfamily of chemotactic cytokines which includes IL-8. We have used Northern and Southern blot analyses to compare the expression of CINC-related and GRO transcripts in human cells and to compare the hybridization patterns of CINC and GRO probes in human and rat genomic DNA. Our data indicate that rat CINC is encoded by a single gene unlike GRO-alpha, -beta and -gamma which are encoded by three distinct genes and that they are the nearest homologs to each other from their respective species.

MeSH Terms

Animals Base Sequence Blotting, Northern Blotting, Southern Cell Line Chemokine CXCL1 Chemokines, CXC Chemotactic Factors/genetics DNA/genetics,isolation & purification DNA, Neoplasm/genetics,isolation & purification Growth Substances/genetics Humans Intercellular Signaling Peptides and Proteins Interleukin-8/genetics Molecular Sequence Data Neoplasm Proteins/genetics Oligonucleotide Probes Rats Restriction Mapping Sequence Homology, Nucleic Acid Transcription, Genetic Tumor Cells, Cultured

Chemicals

CXCL1 protein, human Chemokine CXCL1 Chemokines, CXC Chemotactic Factors Cxcl1 protein, rat DNA, Neoplasm Growth Substances Intercellular Signaling Peptides and Proteins Interleukin-8 Neoplasm Proteins Oligonucleotide Probes DNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Zagorski J

Department of Health Sciences, Monsanto Company, St. Louis, MO 63167.

DeLarco J E

Article Info

Journal

Biochemical and biophysical research communications

Abbr.

Biochem Biophys Res Commun

ISSN

0006-291X

DOI

10.1006/bbrc.1993.1017

Published

1993-01-15

Pages

104-10

Language

English

Region

United States

NLM ID

0372516

Subset

External Links

PubMed source DOI: 10.1006/bbrc.1993.1017 View journal details

Analysis Services

Rat CINC (cytokine-induced neutrophil chemoattractant) is the homolog of the human GRO proteins but is encoded by a single gene.

Contact

WeChat Official Account