T-cell-depleted maternal bone marrow transplantation for siblings with X-linked severe combined immunodeficiency.

The Journal of pediatrics ·Vol. 122 ·No. 2 ·1993-02-00 ·Pages 289-91

Himelstein BP, Puck J, August C, Pierson G, Bunin N

Abstract

Prenatal diagnosis of X-linked severe combined immunodeficiency in a male fetus made possible elective neonatal bone marrow transplantation before onset of symptoms. Bone marrow transplantation was performed by using T-cell-depleted maternal marrow that had been cryopreserved 2 years earlier, at the time that his older affected brother underwent transplantation. The second patient had less morbidity and more rapid reconstitution of his immune function.

MeSH Terms

Alleles Amniocentesis Bone Marrow Transplantation/methods,pathology Cryopreservation Female Fetal Diseases/genetics Genetic Linkage Humans Infant Infant, Newborn Male Polymorphism, Genetic Pregnancy Severe Combined Immunodeficiency/genetics,surgery T-Lymphocytes/pathology Tissue Preservation/methods X Chromosome

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Himelstein B P

Division of Oncology, Children's Hospital of Philadelphia, PA 19104.

Puck J

August C

Pierson G

Bunin N

Article Info

Journal

The Journal of pediatrics

Abbr.

J Pediatr

ISSN

0022-3476

DOI

10.1016/s0022-3476(06)80135-6

Published

1993-02-00

Pages

289-91

Language

English

Region

United States

NLM ID

0375410

Subset

External Links

PubMed source DOI: 10.1016/s0022-3476(06)80135-6 View journal details

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T-cell-depleted maternal bone marrow transplantation for siblings with X-linked severe combined immunodeficiency.

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