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PMID: 8435476 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Type IV collagenases in invasive tumors.

Breast cancer research and treatment ·Vol. 24 ·No. 3 ·1993-00-00 ·Pages 209-18

Tryggvason K, Höyhtyä M, Pyke C

Abstract

The matrix metalloproteinases appear to be elevated in tumors with metastatic potential, and may well be involved in penetration of the basement membrane and degradation of extracellular proteins including type IV collagen. An imbalance between the 72 kDa and 92 kDa type IV collagenases and the associated tissue inhibitors of these metalloproteinases (TIMPs) may therefore have a role in the invasive phenotype. Cultured tumor cells with invasive potential secrete both type IV collagenases, though in tumors there is some evidence that the 72 kDa form at least may be produced by stromal cells at the invading tumor front rather than primarily by the tumor cells themselves, while the 92 kDa form may be synthesized in macrophages near the front. These collagenases are elevated in invasive as compared with in situ tumor components, but their specific roles and prognostic significance are not yet established.

MeSH Terms
Animals Breast Neoplasms/enzymology,pathology Collagenases/chemistry,metabolism Female Gene Expression Regulation, Enzymologic Humans Matrix Metalloproteinase Inhibitors Metalloendopeptidases/antagonists & inhibitors,chemistry,metabolism Neoplasm Invasiveness Neoplasms/enzymology,pathology
Chemicals
Matrix Metalloproteinase Inhibitors Collagenases Metalloendopeptidases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tryggvason K
Biocenter, University of Oulu, Finland.
Höyhtyä M
Pyke C
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46 references, click to expand
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Article Info
Journal
Breast cancer research and treatment
Abbr.
Breast Cancer Res Treat
ISSN
0167-6806
DOI
10.1007/BF01833261
Published
1993-00-00
Pages
209-18
Language
English
Region
Netherlands
NLM ID
8111104
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01833261 View journal details
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