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PMID: 8437240 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Simian immunodeficiency virus-specific CD8+ lymphocyte response in acutely infected rhesus monkeys.

Journal of virology ·Vol. 67 ·No. 3 ·1993-03-00 ·Pages 1707-11

Yasutomi Y, Reimann KA, Lord CI, Miller MD, Letvin NL

Abstract

To assess the possible role of cytotoxic T lymphocytes (CTLs) in containing the spread of human immunodeficiency virus in acutely infected individuals, the temporal evolution of the virus-specific CD8+ lymphocyte response was defined in simian immunodeficiency virus of macaques (SIVmac)-infected rhesus monkeys. A brief period of SIVmac plasma antigenemia was seen 9 to 16 days following intravenous infection with SIVmac, ending as the absolute number of CD8+ peripheral blood lymphocytes (PBLs) increased. In a prospective assessment of the ability of CD8+ lymphocytes of these monkeys to suppress SIVmac replication in autologous PBLs, inhibitory activity was detected as early as 4 days, with a more pronounced effect 12 to 16 days following infection. SIVmac Gag- and Nef-specific CD8+ effector cell activities were demonstrable in PBLs of animals by 2 weeks following virus inoculation. In fact, SIVmac-specific CTL precursors were documented in the PBLs of rhesus monkeys 4 to 6 days after SIVmac infection. These studies indicate that AIDS virus-specific CD8+ CTLs are present in PBLs within days of infection and may play an important role in containing the early spread of virus.

MeSH Terms
Acute Disease Animals CD8 Antigens/immunology Gene Products, gag/immunology Immunity, Cellular Immunity, Innate/immunology Macaca mulatta/immunology Simian Acquired Immunodeficiency Syndrome/immunology Simian Immunodeficiency Virus/immunology,pathogenicity T-Lymphocytes, Cytotoxic/immunology Time Factors Virulence
Chemicals
CD8 Antigens Gene Products, gag
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Yasutomi Y
Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772-9102.
Reimann K A
Lord C I
Miller M D
Letvin N L
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.67.3.1707-1711.1993
Published
1993-03-00
Pages
1707-11
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC237548
Subset
IM
Grants
NIAID NIH HHS · AI20729 · United States
NIAID NIH HHS · AI26507 · United States
NCI NIH HHS · CA50139 · United States
External Links
PubMed source DOI: 10.1128/JVI.67.3.1707-1711.1993 PMC Full Text View journal details
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