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PMID: 8444785 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Inhibition of Escherichia coli chemotaxis by omega-conotoxin, a calcium ion channel blocker.

Journal of bacteriology ·Vol. 175 ·No. 5 ·1993-03-00 ·Pages 1235-8

Tisa LS, Olivera BM, Adler J

Abstract

Escherichia coli chemotaxis was inhibited by omega-conotoxin, a calcium ion channel blocker. With Tris-EDTA-permeabilized cells, nanomolar levels of omega-conotoxin inhibited chemotaxis without loss of motility. Cells treated with omega-conotoxin swam with a smooth bias, i.e., tumbling was inhibited.

MeSH Terms
Calcium Channel Blockers/pharmacology Chemotaxis/drug effects Escherichia coli/drug effects,physiology Peptides, Cyclic/pharmacology omega-Conotoxins
Chemicals
Calcium Channel Blockers Peptides, Cyclic omega-Conotoxins Conus magus toxin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tisa L S
Department of Biochemistry, University of Wisconsin-Madison 53706-1569.
Olivera B M
Adler J
References (23)
23 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.175.5.1235-1238.1993
Published
1993-03-00
Pages
1235-8
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC193206
Subset
IM
Grants
NIGMS NIH HHS · F32-GM12187 · United States
External Links
PubMed source DOI: 10.1128/jb.175.5.1235-1238.1993 PMC Full Text View journal details
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