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PMID: 8448031 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S. Review

Small actin-binding proteins: the beta-thymosin family.

Current opinion in cell biology ·Vol. 5 ·No. 1 ·1993-02-00 ·Pages 56-62

Nachmias VT

Abstract

Thymosin beta 4 is a major actin monomer binding protein present at high concentration in many vertebrate cells and cell lines. The interactions of actin with thymosin beta 4, actobindin and profilin are compared. Nine beta-thymosins have been identified; six have been shown to bind to actin. Regulation of the synthesis of thymosin beta 10 and thymosin beta 4 has been found in brain development and after stimulation of several cell types, respectively. The extracellular effects of thymosin beta 4 still need clarification.

MeSH Terms
Actins/metabolism Amino Acid Sequence Animals Carrier Proteins/metabolism Contractile Proteins Gene Expression Regulation Humans Mice Microfilament Proteins/genetics,metabolism Molecular Sequence Data Multigene Family Phylogeny Profilins Protozoan Proteins Rats Sequence Alignment Sequence Homology, Amino Acid Species Specificity Thymosin/classification,genetics,metabolism
Chemicals
Actins Carrier Proteins Contractile Proteins Microfilament Proteins PFN1 protein, human Pfn1 protein, mouse Pfn1 protein, rat Profilins Protozoan Proteins actobindin protein, Acanthamoeba Thymosin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Nachmias V T
Department of Cell and Developmental Biology, University of Pennsylvania Medical School, Philadelphia 19104-6058.
Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/s0955-0674(05)80008-0
Published
1993-02-00
Pages
56-62
Language
English
Region
England
NLM ID
8913428
Subset
IM
Grants
NIAMS NIH HHS · AR-40840 · United States
NHLBI NIH HHS · HL-15835 · United States
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1016/s0955-0674(05)80008-0 View journal details
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