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PMID: 8452372 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

In vitro activity of CP-99,219, a new fluoroquinolone, against clinical isolates of gram-positive bacteria.

Antimicrobial agents and chemotherapy ·Vol. 37 ·No. 2 ·1993-02-00 ·Pages 366-70

Eliopoulos GM, Klimm K, Eliopoulos CT, Ferraro MJ, Moellering RC

Abstract

The in vitro activity of the fluoroquinolone CP-99,219 against gram-positive bacteria was compared with those of five other antimicrobial agents. Against ciprofloxacin-susceptible staphylococci and against streptococci, MICs were < or = 0.12 and < or = 0.5 microgram/ml, respectively. CP-99,219 was also more active than ciprofloxacin against ciprofloxacin-resistant staphylococci, most enterococci, Leuconostoc spp., and lactobacilli.

MeSH Terms

Anti-Bacterial Agents/pharmacology Drug Resistance, Microbial Fluoroquinolones Gram-Positive Bacteria/drug effects Gram-Positive Bacterial Infections/microbiology Humans Microbial Sensitivity Tests Naphthyridines/pharmacology

Chemicals

Anti-Bacterial Agents Fluoroquinolones Naphthyridines trovafloxacin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Eliopoulos G M

Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts 02215.

Klimm K

Eliopoulos C T

Ferraro M J

Moellering R C

References (7)

7 references, click to expand

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Comparative in vitro activity of PD 127391, a new fluoroquinolone agent, against susceptible and resistant clinical isolates of gram-positive cocci.
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Multicenter evaluation of the in vitro activities of three new quinolones, sparfloxacin, CI-960, and PD 131,628, compared with the activity of ciprofloxacin against 5,252 clinical bacterial isolates.
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Comparison of Enterococcus raffinosus with Enterococcus avium on the basis of penicillin susceptibility, penicillin-binding protein analysis, and high-level aminoglycoside resistance.
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Rapid dissemination of beta-lactamase-producing, aminoglycoside-resistant Enterococcus faecalis among patients and staff on an infant-toddler surgical ward.
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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.37.2.366

Published

1993-02-00

Pages

366-70

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC187672

Subset

External Links

PubMed source DOI: 10.1128/AAC.37.2.366 PMC Full Text View journal details

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In vitro activity of CP-99,219, a new fluoroquinolone, against clinical isolates of gram-positive bacteria.

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