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PMID: 8457510 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens.

The British journal of ophthalmology ·Vol. 77 ·No. 3 ·1993-03-00 ·Pages 171-5

Dick AD, Cheng YF, McKinnon A, Liversidge J, Forrester JV

Abstract

Current immunotherapy of posterior uveitis is non-specific and limited by drug toxicity and unpredictable relapses on therapy. Alternative modes of therapy being investigated using the rat model of experimental autoimmune uveoretinitis (EAU) have included the induction of tolerance with oral administration of milligram quantities of retinal antigens. In this preliminary report we demonstrate that tolerance to retinal antigens can be induced via the upper respiratory tract with microgram doses of antigen, preventing subsequent induction of EAU.

MeSH Terms
Animals Antigens/immunology Arrestin Autoimmune Diseases/therapy Cattle Desensitization, Immunologic/methods Disease Models, Animal Dose-Response Relationship, Immunologic Eye Proteins/immunology Immune Tolerance/immunology Phosphodiesterase Inhibitors/immunology Rats Rats, Inbred Lew Retina/immunology Retinitis/therapy Uveitis/therapy
Chemicals
Antigens Arrestin Eye Proteins Phosphodiesterase Inhibitors
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Dick A D
Department of Ophthalmology, Medical School, Foresterhill, Aberdeen.
Cheng Y F
McKinnon A
Liversidge J
Forrester J V
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Article Info
Journal
The British journal of ophthalmology
Abbr.
Br J Ophthalmol
ISSN
0007-1161
DOI
10.1136/bjo.77.3.171
Published
1993-03-00
Pages
171-5
Language
English
Region
England
NLM ID
0421041
PMCID
PMC504465
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1136/bjo.77.3.171 PMC Full Text View journal details
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