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PMID: 8469283 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein.

Nature ·Vol. 362 ·No. 6422 ·1993-04-22 ·Pages 722-8

Andrews NC, Erdjument-Bromage H, Davidson MB, Tempst P, Orkin SH

Abstract

Expression of globin genes in developing erythroid cells is controlled by upstream locus control regions. Activity of these regions in vivo requires an erythroid-specific nuclear factor (NF-E2) that binds AP-1-like recognition sites. Its tissue-specific component (p45 NF-E2) has been characterized by complementary DNA cloning as a new basic region-leucine zipper protein which dimerizes with a ubiquitous partner to form native NF-E2.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Binding Sites Cell Line Cloning, Molecular Consensus Sequence DNA/metabolism DNA-Binding Proteins/chemistry,genetics,metabolism Erythrocytes/cytology,metabolism Erythroid-Specific DNA-Binding Factors Globins/genetics Hematopoiesis Leucine Zippers/genetics Leukemia, Erythroblastic, Acute Mice Molecular Sequence Data Mutation NF-E2 Transcription Factor NF-E2 Transcription Factor, p45 Subunit Peptides/genetics,metabolism Transcription Factors/chemistry,genetics,metabolism Transfection Tumor Cells, Cultured Zinc Fingers/genetics
Chemicals
DNA-Binding Proteins Erythroid-Specific DNA-Binding Factors NF-E2 Transcription Factor NF-E2 Transcription Factor, p45 Subunit Nfe2 protein, mouse Peptides Transcription Factors Globins DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Andrews N C
Children's Hospital, Dana-Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115.
Erdjument-Bromage H
Davidson M B
Tempst P
Orkin S H
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
Published
1993-04-22
Pages
722-8
Language
English
Region
England
NLM ID
0410462
Subset
IM
Databases
GENBANK
L09600
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