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PMID: 847477 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain.

Science (New York, N.Y.) ·Vol. 196 ·No. 4287 ·1977-04-15 ·Pages 326-8

Burt DR, Creese I, Snyder SH

Abstract

Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25% increase in striatal dopamine receptor binding assayed with [3H]haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.

MeSH Terms

Animals Apomorphine/pharmacology Corpus Striatum/metabolism Dextroamphetamine/pharmacology Dose-Response Relationship, Drug Fluphenazine/pharmacology Haloperidol/metabolism,pharmacology Kinetics Rats Receptors, Dopamine/metabolism Reserpine/pharmacology Time Factors Tranquilizing Agents/pharmacology

Chemicals

Receptors, Dopamine Tranquilizing Agents Reserpine Haloperidol Apomorphine Fluphenazine Dextroamphetamine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Burt D R

Creese I

Snyder S H

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.847477

Published

1977-04-15

Pages

326-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.847477 View journal details

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