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PMID: 8495192 Published · ppublish English Journal Article Review

The curious case of protein splicing: mechanistic insights suggested by protein semisynthesis.

Protein science : a publication of the Protein Society ·Vol. 2 ·No. 5 ·1993-05-00 ·Pages 697-705

Wallace CJ

Abstract

The gradual accumulation of examples of protein splicing, in which a nested intervening sequence is spliced out of the interior of a polyprotein precursor, suggests that this curious phenomenon might prove to have universal phylogenetic distribution and biological significance. The known examples are reviewed, with the aim of establishing underlying patterns, and a generalized mechanism of autocatalytic protein splicing is proposed. The testable consequences of such a proposal and the possible evolutionary origins of the phenomenon are discussed.

MeSH Terms
Amino Acid Sequence Concanavalin A/biosynthesis DNA-Directed DNA Polymerase/biosynthesis Endodeoxyribonucleases/biosynthesis Models, Biological Molecular Sequence Data Protein Precursors/metabolism Protein Processing, Post-Translational Proton-Translocating ATPases Rec A Recombinases/biosynthesis Saccharomyces cerevisiae Proteins
Chemicals
Protein Precursors Saccharomyces cerevisiae Proteins Concanavalin A Rec A Recombinases Tli polymerase DNA-Directed DNA Polymerase Endodeoxyribonucleases Proton-Translocating ATPases VMA1 protein, S cerevisiae
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Wallace C J
Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada.
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30 references, click to expand
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Article Info
Journal
Protein science : a publication of the Protein Society
Abbr.
Protein Sci
ISSN
0961-8368
DOI
10.1002/pro.5560020501
Published
1993-05-00
Pages
697-705
Language
English
Region
United States
NLM ID
9211750
PMCID
PMC2142502
Subset
IM
External Links
PubMed source DOI: 10.1002/pro.5560020501 PMC Full Text View journal details
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