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PMID: 8503146 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Citrate and urease-induced crystallization in synthetic and human urine.

Urological research ·Vol. 21 ·No. 2 ·1993-03-00 ·Pages 109-15

Wang YH, Grenabo L, Hedelin H, McLean RJ, Nickel JC, Pettersson S

Abstract

The effects of citrate on the different phases of urease-induced crystallization were studied using Coulter counter techniques and optical microscopy. Citrate increased urine pH and markedly delayed the initiation of the crystallization (nucleation) in both human and synthetic urine. In synthetic urine, particle aggregation and especially particle growth were delayed and inhibited by citrate. In human urine, aggregation was distinctly inhibited by citrate. It appears that the susceptibility of urine to form crystals in the presence of urease activity is influenced by its citrate concentration.

MeSH Terms
Adult Citrates/pharmacology,urine Crystallization Female Humans Hydrogen-Ion Concentration In Vitro Techniques Male Urease/pharmacology,urine Urinary Calculi/chemistry,etiology,urine
Chemicals
Citrates Urease
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Wang Y H
Department of Urology, Sahlgrenska sjukhuset, University of Göteborg, Sweden.
Grenabo L
Hedelin H
McLean R J
Nickel J C
Pettersson S
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19 references, click to expand
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Article Info
Journal
Urological research
Abbr.
Urol Res
ISSN
0300-5623
DOI
10.1007/BF01788828
Published
1993-03-00
Pages
109-15
Language
English
Region
Germany
NLM ID
0364311
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01788828 View journal details
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