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PMID: 8504247 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Effects of DNA methylation on DNA-binding proteins and gene expression.

Current opinion in genetics & development ·Vol. 3 ·No. 2 ·1993-04-00 ·Pages 226-31

Tate PH, Bird AP

Abstract

DNA methyltransferase is needed for normal development, perhaps because DNA methylation plays a part in the control of gene activity. It is clear that the methylation of promoters often leads to repression of transcription. Studies of the mechanism suggest that repression may either result from the direct effects of methylation on transcription factors, or may be indirectly caused by repressor proteins that bind to methylated DNA. Current evidence suggests that both mechanisms can be involved.

MeSH Terms

5-Methylcytosine Amino Acid Sequence Animals Base Sequence Consensus Sequence Cytosine/analogs & derivatives,physiology DNA/genetics,metabolism DNA (Cytosine-5-)-Methyltransferases/metabolism DNA-Binding Proteins/metabolism Gene Expression Regulation Humans Methylation Models, Genetic Molecular Sequence Data Promoter Regions, Genetic Protein Binding Repressor Proteins/metabolism Transcription Factors/metabolism Transcription, Genetic

Chemicals

DNA-Binding Proteins Repressor Proteins Transcription Factors 5-Methylcytosine Cytosine DNA DNA (Cytosine-5-)-Methyltransferases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Tate P H

Institute of Cell and Molecular Biology, University of Edinburgh, Scotland.

Bird A P

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/0959-437x(93)90027-m

Published

1993-04-00

Pages

226-31

Language

English

Region

England

NLM ID

9111375

Subset

External Links

PubMed source DOI: 10.1016/0959-437x(93)90027-m View journal details

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