Regulation of the HNF-1 homeodomain proteins by DCoH.

Current opinion in genetics & development ·Vol. 3 ·No. 2 ·1993-04-00 ·Pages 246-53

Hansen LP, Crabtree GR

Abstract

The pattern of expression of homeodomain proteins often exceeds their apparent domain of activity. Tissue-specific proteins that modulate the in vivo activity of homeodomain proteins have been proposed to account for this functional restriction. The first identified example of such an accessory protein is DCoH, which confers transcriptional activity to the hepatocyte nuclear factor 1 and provides a model of how other accessory factors might modulate the function of homeodomain proteins.

MeSH Terms

Animals Base Sequence DNA/metabolism DNA-Binding Proteins/metabolism Gene Expression Regulation Hepatocyte Nuclear Factor 1 Hepatocyte Nuclear Factor 1-alpha Hepatocyte Nuclear Factor 1-beta Humans Hydro-Lyases/metabolism Models, Biological Molecular Sequence Data Nuclear Proteins Protein Binding Protein Conformation Recombinant Fusion Proteins/metabolism Transcription Factors/physiology Transcription, Genetic Transcriptional Activation

Chemicals

DNA-Binding Proteins HNF1A protein, human HNF1B protein, human Hepatocyte Nuclear Factor 1-alpha Nuclear Proteins Recombinant Fusion Proteins Transcription Factors Hepatocyte Nuclear Factor 1 Hepatocyte Nuclear Factor 1-beta DNA Hydro-Lyases pterin-4a-carbinolamine dehydratase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hansen L P

Beckman Center for Molecular and Genetic Medicine, Stanford University Medical School, CA 94305.

Crabtree G R

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/0959-437x(93)90030-s

Published

1993-04-00

Pages

246-53

Language

English

Region

England

NLM ID

9111375

Subset

External Links

PubMed source DOI: 10.1016/0959-437x(93)90030-s View journal details

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Regulation of the HNF-1 homeodomain proteins by DCoH.

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