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PMID: 8506281 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A proposal for a new approach to a preventive vaccine against human immunodeficiency virus type 1.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 90 ·No. 10 ·1993-05-15 ·Pages 4419-20

Temin HM

Abstract

Human immunodeficiency virus type 1 (HIV-1) is a more complex retrovirus, coding for several accessory proteins in addition to the structural proteins (Gag, Pol, and Env) that are found in all retroviruses. More complex retroviruses have not been isolated from birds, and simpler retroviruses have not been isolated from humans. However, the proviruses of many endogenous simpler retroviruses are present in the human genome. These observations suggest that humans can mount a successful protective response against simpler retroviruses, whereas birds cannot. Thus, humans might be able to mount a successful protective response to infection with a simpler HIV-1. As a model, a simpler bovine leukemia virus which is capable of replicating has been constructed; a simpler HIV-1 could be constructed in a similar fashion. I suggest that such a simpler HIV-1 would be a safe and effective vaccine against HIV-1.

MeSH Terms
AIDS Vaccines Genes, env Genes, gag Genes, pol Genetic Vectors HIV/genetics,immunology HIV Infections/prevention & control Humans Retroviridae/genetics Vaccines, Synthetic
Chemicals
AIDS Vaccines Vaccines, Synthetic
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Temin H M
McArdle Laboratory, Madison, WI 53706.
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.90.10.4419
Published
1993-05-15
Pages
4419-20
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC46522
Subset
IM
Grants
NCI NIH HHS · CA07175 · United States
NCI NIH HHS · CA22443 · United States
External Links
PubMed source DOI: 10.1073/pnas.90.10.4419 PMC Full Text View journal details
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