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PMID: 8509455 Published · ppublish English Journal Article

Porters versus rowers: a unified stochastic model of motor proteins.

The Journal of cell biology ·Vol. 121 ·No. 6 ·1993-06-00 ·Pages 1357-68

Leibler S, Huse DA

Abstract

We present a general phenomenological theory for chemical to mechanical energy transduction by motor enzymes which is based on the classical "tight-coupling" mechanism. The associated minimal stochastic model takes explicitly into account both ATP hydrolysis and thermal noise effects. It provides expressions for the hydrolysis rate and the sliding velocity, as functions of the ATP concentration and the number of motor enzymes. It explains in a unified way many results of recent in vitro motility assays. More importantly, the theory provides a natural classification scheme for the motors: it correlates the biochemical and mechanical differences between "porters" such as cellular kinesins or dyneins, and "rowers" such as muscular myosins or flagellar dyneins.

MeSH Terms
Actins/physiology Adenosine Triphosphate/metabolism Animals Biological Transport/physiology Cytoplasm Dyneins/physiology Energy Metabolism Flagella Friction Kinesins/physiology Kinetics Microtubules/metabolism Models, Biological Models, Chemical Models, Statistical Movement/physiology Muscles/metabolism Myosins/physiology Protein Binding Stochastic Processes
Chemicals
Actins Adenosine Triphosphate Myosins Dyneins Kinesins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Leibler S
Department of Physics, Princeton University, New Jersey 08544.
Huse D A
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35 references, click to expand
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.121.6.1357
Published
1993-06-00
Pages
1357-68
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2119711
Subset
IM
External Links
PubMed source DOI: 10.1083/jcb.121.6.1357 PMC Full Text View journal details
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