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PMID: 8516813 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation.

Transplantation ·Vol. 55 ·No. 6 ·1993-06-00 ·Pages 1272-7

Starzl TE, Demetris AJ, Trucco M, Zeevi A, Ramos H, Terasaki P, Rudert WA, Kocova M, Ricordi C, Ildstad S

Abstract

Chimerism was demonstrated with immunocytochemical and/or polymerase chain reaction techniques in kidney allografts and in the native skin, lymph nodes, or blood of 5 of 5 patients who received continuously functioning renal transplants from 1 or 2 haplotype HLA mismatched consanguineous donors (4 parents, 1 aunt) 27-29 years ago. In the 4 cases where the kidney donor still was alive to provide stimulator lymphocytes for testing, these provoked no (n = 2) or modest (n = 2) MLR in contrast to vigorous MLR to third party lymphocytes. In all 4 cases, the donor cells failed to generate in vitro cytotoxic effector cells (cell-mediated lymphocytotoxicity). These findings are in accord with the hypothesis that cell migration, repopulation, and chimerism are seminal events that define graft acceptance and ultimately can lead to acquired donor-specific nonresponsiveness (tolerance).

MeSH Terms
Adult Chimera Female Graft Survival HLA-DR Antigens/analysis Humans Immune Tolerance Kidney Transplantation/immunology,pathology Lymphocyte Culture Test, Mixed Male Polymerase Chain Reaction Time Factors
Chemicals
HLA-DR Antigens
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Starzl T E
Pittsburgh Transplant Institute, Pennsylvania.
Demetris A J
Trucco M
Zeevi A
Ramos H
Terasaki P
Rudert W A
Kocova M
Ricordi C
Ildstad S
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Article Info
Journal
Transplantation
Abbr.
Transplantation
ISSN
0041-1337
DOI
10.1097/00007890-199306000-00012
Published
1993-06-00
Pages
1272-7
Language
English
Region
United States
NLM ID
0132144
PMCID
PMC2953386
Subset
IM
Grants
NIDDK NIH HHS · R01 DK029961-19 · United States
NIDDK NIH HHS · DK 29961 · United States
External Links
PubMed source DOI: 10.1097/00007890-199306000-00012 PMC Full Text View journal details
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