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PMID: 8516849 Published · ppublish English Journal Article Review

The multistep nature of cancer.

Trends in genetics : TIG ·Vol. 9 ·No. 4 ·1993-04-00 ·Pages 138-41

Vogelstein B, Kinzler KW

Abstract

Cancer is a distinct type of genetic disease in which not one, but several, mutations are required. Each mutation drives a wave of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy. Three to six such mutations appear to be required to complete this process.

Related Genes
APC DCC k-ras p53
MeSH Terms
Adult Aged Aged, 80 and over Animals Animals, Genetically Modified Cell Transformation, Neoplastic/genetics Gene Expression Regulation, Neoplastic Humans Mice Middle Aged Mutation Neoplasms/epidemiology,genetics Oncogenes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Vogelstein B
Johns Hopkins Oncology Center, Baltimore, MD 21231.
Kinzler K W
Article Info
Journal
Trends in genetics : TIG
Abbr.
Trends Genet
ISSN
0168-9525
DOI
10.1016/0168-9525(93)90209-z
Published
1993-04-00
Pages
138-41
Language
English
Region
England
NLM ID
8507085
Subset
IM
External Links
PubMed source DOI: 10.1016/0168-9525(93)90209-z View journal details
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