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PMID: 8517852 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Protein trafficking along the exocytotic pathway.

BioEssays : news and reviews in molecular, cellular and developmental biology ·Vol. 15 ·No. 4 ·1993-04-00 ·Pages 231-8

Hong W, Tang BL

Abstract

Proteins of the exocytotic (secretory) pathway are initially targeted to the endoplasmic reticulum (ER) and then translocated across and/or inserted into the membrane of the ER. During their anterograde transport with the bulk of the membrane flow along the exocytotic pathway, some proteins are selectively retained in various intracellular compartments, while others are sorted to different branches of the pathway. The signals or structural motifs that are involved in these selective targeting processes are being revealed and investigations into the mechanistic nature of these processes are actively underway.

Related Genes
ERD2 SEC20 SED4
MeSH Terms
Amino Acid Sequence Animals Biological Transport Cell Membrane/physiology Endoplasmic Reticulum/physiology Exocytosis Golgi Apparatus/physiology Lysosomes/physiology Mammals/physiology Models, Biological Molecular Sequence Data Protein Processing, Post-Translational Proteins/metabolism
Chemicals
Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hong W
Membrane Biology Laboratory, National University of Singapore.
Tang B L
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Article Info
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
Abbr.
Bioessays
ISSN
0265-9247
DOI
10.1002/bies.950150403
Published
1993-04-00
Pages
231-8
Language
English
Region
United States
NLM ID
8510851
PMCID
PMC7161809
Subset
IM
External Links
PubMed source DOI: 10.1002/bies.950150403 PMC Full Text View journal details
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