Requirement for Xist in X chromosome inactivation.

Nature ·Vol. 379 ·No. 6561 ·1996-01-11 ·Pages 131-7

Penny GD, Kay GF, Sheardown SA, Rastan S, Brockdorff N

Abstract

The Xist gene has been proposed as a candidate for the X inactivation centre, the master regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has been supported solely by indirect evidence. Here we describe gene targeting of Xist, and provide evidence for its absolute requirement in the process of X chromosome inactivation.

MeSH Terms

Alleles Animals Base Sequence Cell Line Chimera Clone Cells DNA Primers Dosage Compensation, Genetic Embryo, Mammalian Female Gene Targeting Male Mice Mice, Inbred BALB C Mice, Inbred C3H Molecular Sequence Data Mutagenesis RNA, Long Noncoding RNA, Untranslated Restriction Mapping Stem Cells Transcription Factors/genetics X Chromosome/genetics

Chemicals

DNA Primers RNA, Long Noncoding RNA, Untranslated Transcription Factors XIST non-coding RNA

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Penny G D

Section of Comparative Biology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

Kay G F

Sheardown S A

Rastan S

Brockdorff N

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/379131a0

Published

1996-01-11

Pages

131-7

Language

English

Region

England

NLM ID

0410462

Subset

Corrections

CommentIn

PMID: 8538759

External Links

PubMed source DOI: 10.1038/379131a0 View journal details

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Requirement for Xist in X chromosome inactivation.

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