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PMID: 8540729 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Resistance of Candida albicans biofilms to antifungal agents in vitro.

Antimicrobial agents and chemotherapy ·Vol. 39 ·No. 9 ·1995-09-00 ·Pages 2128-31

Hawser SP, Douglas LJ

Abstract

Biofilms formed by Candida albicans on small discs of catheter material were resistant to the action of five clinically important antifungal agents as determined by [3H]leucine incorporation and tetrazolium reduction assays. Fluconazole showed the greatest activity, and amphotericin B showed the least activity against biofilm cells. These findings were confirmed by scanning electron microscopy of the biofilms.

MeSH Terms
Antifungal Agents/pharmacology Biofilms/drug effects Candida albicans Humans Leucine/metabolism Microbial Sensitivity Tests Microscopy, Electron, Scanning Stomatitis, Denture/microbiology
Chemicals
Antifungal Agents Leucine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hawser S P
Laboratory of Microbiology, University of Glasgow, United Kingdom.
Douglas L J
References (10)
10 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.39.9.2128
Published
1995-09-00
Pages
2128-31
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC162894
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.39.9.2128 PMC Full Text View journal details
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