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PMID: 8549361 Published · ppublish English Journal Article Review

Epidemiology of quinolone resistance: Europe and North and South America.

Drugs ·Vol. 49 Suppl 2 ·1995-00-00 ·Pages 36-42

Goldstein FW, Acar JF

Abstract

After nearly 10 years of fluoroquinolone usage for a wide range of bacterial infections, a striking difference has been observed in the incidence of bacterial resistance to fluoroquinolones between bacteria responsible for community- and hospital-acquired infections, respectively. Resistance is only rarely encountered among common pathogens. In most studies, 97 to 100% of all pathogens are fully susceptible to fluoroquinolones. In contrast, resistance to fluoroquinolones has emerged and increased among bacteria responsible for nosocomial infections. The incidence of resistance to fluoroquinolones varies between bacterial species, clinical settings and countries, and is related to local epidemic spread of a few clones. The highest incidence of resistance is observed in Pseudomonas aeruginosa, Acinetobacter spp., Serratia marcescens and, particularly, methicillin-resistant Staphylococcus aureus (MRSA): some investigators have reported 95 to 100% fluoroquinolone resistance among MRSA. Follow-up of trends in the resistance to fluoroquinolones based upon surveillance programmes are needed.

MeSH Terms
4-Quinolones Animals Anti-Infective Agents/pharmacology,therapeutic use Bacteria/drug effects,genetics Bacterial Infections/drug therapy,epidemiology,microbiology Drug Resistance, Microbial Europe/epidemiology Humans North America/epidemiology South America/epidemiology
Chemicals
4-Quinolones Anti-Infective Agents
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Goldstein F W
Laboratoire de Microbiologie Médicale, Fondation Hôpital Saint-Joseph, Paris, France.
Acar J F
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Article Info
Journal
Drugs
Abbr.
Drugs
ISSN
0012-6667
DOI
10.2165/00003495-199500492-00007
Published
1995-00-00
Pages
36-42
Language
English
Region
New Zealand
NLM ID
7600076
Subset
IM
External Links
PubMed source DOI: 10.2165/00003495-199500492-00007 View journal details
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