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PMID: 8549455 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Application of biologic markers to studies of environmental risks in children and the developing fetus.

Environmental health perspectives ·Vol. 103 Suppl 6 ·1995-09-00 ·Pages 105-10

Whyatt RM, Perera FP

Abstract

Young children and the developing fetus may be more susceptible to effects of environmental toxicants than adults due to differential exposure patterns and developmental immaturities. Biologic markers offer the potential of quantitative dosimeters of biologic dose and/or indices of biologic effect associated with fetal/childhood exposures. They can facilitate evaluation of interindividual variability in response and the magnitude of age-related susceptibilities. Thus far, biologic markers have not been widely used in developmental epidemiology of environmental exposures. Research by our group and others has seen elevations in biologic markers in samples from children and fetal tissue associated with a spectrum of environmental exposures, including tobacco smoke (active and passive), ambient pollution, and dietary contaminants. Studies also suggest that biologic markers can provide powerful dosimeters for investigating reproductive effects. Validation of biologic markers offering the greatest promise for developmental epidemiology is needed.

MeSH Terms
Adult Biomarkers/analysis Child Environmental Exposure Environmental Pollutants/toxicity Epidemiologic Methods Fetus/drug effects Food Contamination Humans Tobacco Smoke Pollution/adverse effects
Chemicals
Biomarkers Environmental Pollutants Tobacco Smoke Pollution
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Whyatt R M
Columbia University School of Public Health, New York, NY 10032, USA.
Perera F P
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Article Info
Journal
Environmental health perspectives
Abbr.
Environ Health Perspect
ISSN
0091-6765
DOI
10.1289/ehp.95103s6105
Published
1995-09-00
Pages
105-10
Language
English
Region
United States
NLM ID
0330411
PMCID
PMC1518899
Subset
IM
Grants
NCI NIH HHS · CA51196 · United States
PHS HHS · P01-E505249 · United States
NIEHS NIH HHS · R01-ES06722 · United States
External Links
PubMed source DOI: 10.1289/ehp.95103s6105 PMC Full Text View journal details
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