Home LiteratureArticle Details
PMID: 8549760 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Molecular and functional characterization of a rat brain Kv beta 3 potassium channel subunit.

FEBS letters ·Vol. 377 ·No. 3 ·1995-12-27 ·Pages 383-9

Heinemann SH, Rettig J, Wunder F, Pongs O

Abstract

A novel potassium channel beta-subunit (Kv beta 3) was cloned from rat brain being the third member of a Kv beta subunit gene family. It is a protein of 403 amino acid residues with a 68% amino acid sequence homology to Kv beta 1.1. Kv beta 3 is primarily expressed in rat brain having a distribution distinct to those of Kv beta 1.1 and Kv beta 2. This subunit also has a long N-terminal structure and induces inactivation in N-terminal deleted Kv1.4 but not in other members of the Kv1 channel family. Similarly to Kv beta 1.1, the Kv beta 3-induced inactivation is regulated by the intracellular redox potential.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Brain/anatomy & histology Brain Chemistry DNA, Complementary/genetics Electric Conductivity Gene Library Large-Conductance Calcium-Activated Potassium Channel beta Subunits Molecular Sequence Data Multigene Family Nerve Tissue Proteins/genetics,isolation & purification,metabolism Oocytes Patch-Clamp Techniques Potassium Channels/genetics,isolation & purification,metabolism Protein Conformation RNA, Messenger/analysis Rats Sequence Analysis, DNA Sequence Homology, Amino Acid Tissue Distribution Xenopus
Chemicals
DNA, Complementary Kcnab3 protein, rat Large-Conductance Calcium-Activated Potassium Channel beta Subunits Nerve Tissue Proteins Potassium Channels RNA, Messenger
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Heinemann S H
Max-Planck-Gesellschaft z.Ed.W. c.V. AG Molecular und zelluläre, Biophysik, Jena, Germany.
Rettig J
Wunder F
Pongs O
Article Info
Journal
FEBS letters
Abbr.
FEBS Lett
ISSN
0014-5793
DOI
10.1016/0014-5793(95)01377-6
Published
1995-12-27
Pages
383-9
Language
English
Region
England
NLM ID
0155157
Subset
IM
Databases
GENBANK
X70662, X76723
External Links
PubMed source DOI: 10.1016/0014-5793(95)01377-6 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2