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PMID: 8551621 Published · ppublish English Journal Article

Genetic basis for resistance to polytropic murine leukemia viruses in the wild mouse species Mus castaneus.

Journal of virology ·Vol. 70 ·No. 2 ·1996-02-00 ·Pages 830-3

Lyu MS, Kozak CA

Abstract

Cultured cells derived from the wild mouse species Mus castaneus were found to be uniquely resistant to exogenous infection by polytropic mink cell focus-forming (MCF) murine leukemia viruses (MuLVs). This MCF MuLV resistance is inherited as a genetically recessive trait in the progeny of F1 crosses between M. castaneus and MCF MuLV-susceptible laboratory mice. Examination of the progeny of backcrosses demonstrated that susceptibility is inherited as a single gene which maps to chromosome 1. The map location of this gene places it at or near the locus Rmc1, the gene encoding the receptor for MCF/xenotropic MuLVs, suggesting that resistance is mediated by the M. castaneus allele of this receptor.

MeSH Terms
Animals Animals, Wild Cell Line Cells, Cultured Chromosome Mapping Genes, Recessive Immunity, Innate/genetics Mice Mice, Inbred AKR Mice, Inbred DBA Mink Cell Focus-Inducing Viruses/genetics,physiology Muridae/genetics,virology Receptors, Virus/genetics Xenotropic and Polytropic Retrovirus Receptor
Chemicals
Receptors, Virus Xenotropic and Polytropic Retrovirus Receptor Xpr1 protein, mouse
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lyu M S
Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892-0460, USA.
Kozak C A
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.70.2.830-833.1996
Published
1996-02-00
Pages
830-3
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC189885
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.70.2.830-833.1996 PMC Full Text View journal details
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