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PMID: 8557370 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Invasin production by Yersinia pestis is abolished by insertion of an IS200-like element within the inv gene.

Infection and immunity ·Vol. 64 ·No. 1 ·1996-01-00 ·Pages 375-9

Simonet M, Riot B, Fortineau N, Berche P

Abstract

The two enteropathogens Yersinia pseudotuberculosis and Yersinia enterocolitica penetrate eukaryotic cells in vitro through invasin, a surface-exposed protein. In contrast, Yersinia pestis, the causative agent of plague, is unable to enter mammalian cell lines, although the inv gene is present on its chromosome. Although 99.3% identical to the inv gene of Y. pseudotuberculosis, the Y. pestis inv gene was disrupted in its central region by a 708-bp IS200-like element. Multiple copies of this insertion sequence element were found within the genome of the plague bacillus.

MeSH Terms
Adhesins, Bacterial Amino Acid Sequence Bacterial Adhesion/genetics Bacterial Proteins/biosynthesis,genetics Base Sequence Biological Evolution DNA Transposable Elements Genes, Bacterial Molecular Sequence Data Polymerase Chain Reaction Sequence Analysis, DNA Sequence Homology, Amino Acid Species Specificity Yersinia pestis/genetics,metabolism,pathogenicity
Chemicals
Adhesins, Bacterial Bacterial Proteins DNA Transposable Elements invasin, Yersinia
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Simonet M
INSERM U-411, Faculté de Médecine Necker, Paris, France.
Riot B
Fortineau N
Berche P
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34 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.64.1.375-379.1996
Published
1996-01-00
Pages
375-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC173773
Subset
IM
Databases
GENBANK
U22457
External Links
PubMed source DOI: 10.1128/iai.64.1.375-379.1996 PMC Full Text View journal details
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