Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3.

Science (New York, N.Y.) ·Vol. 271 ·No. 5248 ·1996-01-26 ·Pages 521-5

Vito P, Lacanà E, D'Adamio L

Abstract

Two apoptosis-linked genes, named ALG-2 and ALG-3, were identified by means of a functional selection strategy. ALG-2 codes for a Ca(2+)-binding protein required for T cell receptor-, Fas-, and glucocorticoid-induced cell death. ALG-3, a partial complementary DNA that is homologous to the familial Alzheimer's disease gene STM2, rescues a T cell hybridoma from T cell receptor- and Fas-induced apoptosis. These findings suggest that ALG-2 may mediate Ca(2+)-regulated signals along the death pathway and that cell death may play a role in Alzheimer's disease.

MeSH Terms

Alkaloids/pharmacology Alzheimer Disease/genetics Amino Acid Sequence Animals Apoptosis/drug effects Apoptosis Regulatory Proteins Calcium/metabolism Calcium-Binding Proteins/chemistry,genetics,physiology Cell Line Cloning, Molecular DNA, Complementary Dactinomycin/pharmacology Dexamethasone/pharmacology Fas Ligand Protein Hybridomas Interleukin-2/metabolism Membrane Glycoproteins/metabolism Membrane Proteins/chemistry,genetics,physiology Mice Molecular Sequence Data Presenilin-2 Receptors, Antigen, T-Cell/physiology Signal Transduction Staurosporine T-Lymphocytes Transfection Up-Regulation fas Receptor/metabolism

Chemicals

Alkaloids Apoptosis Regulatory Proteins Calcium-Binding Proteins DNA, Complementary Fas Ligand Protein Fasl protein, mouse Interleukin-2 Membrane Glycoproteins Membrane Proteins Pdcd6 protein, mouse Presenilin-2 Psen2 protein, mouse Receptors, Antigen, T-Cell fas Receptor Dactinomycin Dexamethasone Staurosporine Calcium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Vito P

T Cell Molecular Biology Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Lacanà E

D'Adamio L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.271.5248.521

Published

1996-01-26

Pages

521-5

Language

English

Region

United States

NLM ID

0404511

Subset

Databases

GENBANK

AF035606, U49111, U49112, U57324, U57325

External Links

PubMed source DOI: 10.1126/science.271.5248.521 View journal details

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Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3.

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