Presence of type III collagen in bone from a patient with osteogenesis imperfecta.
Samples of bone from a patient with osteogenesis imperfecta were found to synthesize and contain type III collagen as well as type I collagen. Normal bone contains only type I collagen except in the lining cells of the bone marrow cavities. In the patient's tissue, type III collagen was localized in nonfibrillar structures in discrete areas of the bone. These and previous studies indicate that certain types of osteogenesis imperfecta may be caused by a failure of normal bone maturation and the sites in which the type III collagen is found appear to be defects in the bone.
9 references, click to expand
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Abnormal collagen metabolism in cultured cells in osteogenesis imperfecta.Proc Natl Acad Sci U S A. 1975 Feb;72(2):586-9 PMID: 1054840
-
(Alpha1(3))3 human skin collagen. Release by pepsin digestion and preponderance in fetal life.J Biol Chem. 1974 May 25;249(10):3225-31 PMID: 4598122
-
Collagen polymorphism: characterization of molecules with the chain composition (alpha 1 (3)03 in human tissues.Science. 1974 Mar;183(130):1200-1 PMID: 4812351
-
Isolation and characterization of CNBr peptides of human (alpha 1 (III) )3 collagen and tissue distribution of (alpha 1 (I) )2 alpha 2 and (alpha 1 (III) )3 collagens.J Biol Chem. 1975 Dec 25;250(24):9304-12 PMID: 1194285
-
Bone collagen aggregation abnormalities in osteogenesis imperfecta.Calcif Tissue Res. 1974;17(1):75-9 PMID: 4451878
-
A study on the conversion of procollagen. Release and recovery of procollagen peptides in the culture medium.J Biol Chem. 1973 Nov 10;248(21):7558-64 PMID: 4745782
-
Preparation and use in immunohistology of antibodies specific for type I and type III collagen and procollagen.J Immunol Methods. 1976;12(1-2):117-24 PMID: 792345
-
Disturbance in the regulation of the type of collagen synthesized in a form of osteogenesis imperfecta.Eur J Biochem. 1975 Nov 1;59(1):97-104 PMID: 1107027
-
Molecular weight determination of random coil polypeptides from collagen by molecular sieve chromatography.Anal Biochem. 1968 Nov;26(2):305-12 PMID: 5761170
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