Home LiteratureArticle Details

PMID: 8612770 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Multiple transduction pathways regulate the sodium-extrusion gene PMR2/ENA1 during salt stress in yeast.

FEBS letters ·Vol. 382 ·No. 1-2 ·1996-03-11 ·Pages 89-92

Márquez JA, Serrano R

Abstract

The yeast PMR2/ENA1 gene encodes an ATPase involved in sodium extrusion and induced by NaCl. At low salt concentrations (0.3 M) induction is mediated by the HOG-MAP kinase pathway, a system activated by non-specific osmotic stress. At high salt concentrations (0.8 M) induction is mediated by the protein phosphatase calcineurin and is specific for sodium. Protein kinase A and Sis2p/Hal3p modulate PMR2/ENA1 expression as negative and positive factors, respectively but Sis2p/Hal3p does not participate in the transduction of the salt signal. Salt stress decreases the level of cAMP and the resulting decrease in protein kinase A activity may contribute to HOG-mediated induction.

MeSH Terms

Adenosine Triphosphatases/genetics Calcineurin Calcium-Calmodulin-Dependent Protein Kinases/physiology Calmodulin-Binding Proteins/antagonists & inhibitors,physiology Cation Transport Proteins Cell Cycle Proteins Cyclic AMP-Dependent Protein Kinases/physiology Enzyme Inhibitors/pharmacology Fungal Proteins/physiology Gene Expression Regulation, Fungal/drug effects Genes, Fungal/genetics Genes, Reporter Ion Transport Osmotic Pressure Phosphoprotein Phosphatases/antagonists & inhibitors,physiology Recombinant Fusion Proteins/biosynthesis Saccharomyces cerevisiae/genetics,physiology Saccharomyces cerevisiae Proteins Signal Transduction/physiology Sodium/metabolism Sodium Chloride/pharmacology Sodium-Potassium-Exchanging ATPase Tacrolimus/pharmacology beta-Galactosidase/genetics,metabolism

Chemicals

Calmodulin-Binding Proteins Cation Transport Proteins Cell Cycle Proteins ENA1 protein, S cerevisiae Enzyme Inhibitors Fungal Proteins Recombinant Fusion Proteins SIS2 protein, S cerevisiae Saccharomyces cerevisiae Proteins Sodium Chloride Sodium Cyclic AMP-Dependent Protein Kinases Calcium-Calmodulin-Dependent Protein Kinases Calcineurin Phosphoprotein Phosphatases beta-Galactosidase Adenosine Triphosphatases Sodium-Potassium-Exchanging ATPase Tacrolimus

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Márquez J A

Instituto de Biologia Molecular y Celular de Plantas, Valencia, Spain.

Serrano R

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(96)00157-3

Published

1996-03-11

Pages

89-92

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(96)00157-3 View journal details

Analysis Services

Multiple transduction pathways regulate the sodium-extrusion gene PMR2/ENA1 during salt stress in yeast.

Contact

WeChat Official Account