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PMID: 8617145 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis.

Digestive diseases and sciences ·Vol. 41 ·No. 3 ·1996-03-00 ·Pages 614-20

Mantyh CR, Maggio JE, Mantyh PW, Vigna SR, Pappas TN

Abstract

Pseudomembranous colitis is most often caused by toxins secreted by Clostridium difficile following bowel flora overgrowth after antibiotic use. The secretory and inflammatory effects observed in C. difficile toxin A-induced enterocolitis in the rat ileum are inhibited by CP-96,345, a substance P (SP) receptor antagonist. To determine if SP plays a role in the pathogenesis of human pseudomembranous colitis, SP receptor distribution was examined in a toxin A-positive specimen of bowel. Quantitative receptor autoradiography was used to examine SP receptors in tissue from a patient who tested positive for C. Difficile toxin. SP receptors were massively increased in small blood vessels and lymphoid aggregates in the pseudomembranous colitis bowel in comparison to control specimens. The SP binding was saturable and exhibited similar affinities for SP and CP-96,345. SP may contribute to the inflammatory response in pseudomembranous colitis via a massive increase in SP receptor antagonists may offer a novel therapeutic intervention for pseudomembranous colitis.

MeSH Terms

Adult Blood Vessels/chemistry,metabolism Colon/chemistry,metabolism,pathology Combined Modality Therapy Emergencies Enterocolitis, Pseudomembranous/etiology,metabolism,pathology,therapy Female Humans Lymphoid Tissue/chemistry,metabolism Receptors, Neurokinin-1/analysis,metabolism

Chemicals

Receptors, Neurokinin-1

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Mantyh C R

Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.

Maggio J E

Mantyh P W

Vigna S R

Pappas T N

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Article Info

Journal

Digestive diseases and sciences

Abbr.

Dig Dis Sci

ISSN

0163-2116

DOI

10.1007/BF02282350

Published

1996-03-00

Pages

614-20

Language

English

Region

United States

NLM ID

7902782

Subset

External Links

PubMed source DOI: 10.1007/BF02282350 View journal details

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Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis.

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