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PMID: 8637858 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 93 ·No. 6 ·1996-03-19 ·Pages 2253-6

Steinman L

Abstract

Inflammatory infiltrates in tissue-specific autoimmune disease comprise a collection of T cells with specificity for an antigen in the target organ. These specific cells recruit a population of nonspecific T cells and macrophages. The rare tissue-specific T cells in the infiltrate have the capacity to regulate both the influx and the efflux of cells from the tissue. Administration of an altered peptide ligand for the specific T cell which triggers autoimmunity can lead to the regression of the entire inflammatory ensemble in a few hours. Interleukin 4 is a critical cytokine involved in the regression of the inflammatory infiltrate.

MeSH Terms
Animals Autoantigens/immunology Autoimmunity Humans Immunity, Cellular Inflammation/immunology Receptors, Antigen, T-Cell/physiology T-Lymphocytes/immunology
Chemicals
Autoantigens Receptors, Antigen, T-Cell
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Steinman L
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.93.6.2253
Published
1996-03-19
Pages
2253-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC39781
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.93.6.2253 PMC Full Text View journal details
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