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PMID: 8639691 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Molecular cloning and tissue distribution of rat peptide transporter PEPT2.

Biochimica et biophysica acta ·Vol. 1280 ·No. 2 ·1996-04-26 ·Pages 173-7

Saito H, Terada T, Okuda M, Sasaki S, Inui K

Abstract

A cDNA encoding rat H(+)- coupled peptide transporter PEPT2 was isolated. The cDNA encoded a protein of 729 amino acids with 48% amino acid identity to the rat PEPT1. The mRNA expression of rat PEPT2 was predominant in the kidney. When expressed in Xenopus oocytes, rat PEPT2 stimulated the uptake of bestatin, a dipeptide-like drug.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Blotting, Northern Carrier Proteins/genetics Cloning, Molecular DNA, Complementary Molecular Sequence Data RNA, Messenger/genetics,metabolism Rats Sequence Homology, Amino Acid Symporters Xenopus/genetics

Chemicals

Carrier Proteins DNA, Complementary RNA, Messenger Symporters hydrogen-coupled oligopeptide transporter PepT2

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Saito H

Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Japan.

Terada T

Okuda M

Sasaki S

Inui K

Article Info

Journal

Biochimica et biophysica acta

Abbr.

Biochim Biophys Acta

ISSN

0006-3002

DOI

10.1016/0005-2736(96)00024-7

Published

1996-04-26

Pages

173-7

Language

English

Region

Netherlands

NLM ID

0217513

Subset

Databases

GENBANK

D63149

External Links

PubMed source DOI: 10.1016/0005-2736(96)00024-7

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Molecular cloning and tissue distribution of rat peptide transporter PEPT2.

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