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PMID: 8661702 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Comparative analysis of the cattle and human genomes: detection of ZOO-FISH and gene mapping-based chromosomal homologies.

Mammalian genome : official journal of the International Mammalian Genome Society ·Vol. 7 ·No. 4 ·1996-04-00 ·Pages 297-302

Chowdhary BP, Frönicke L, Gustavsson I, Scherthan H

Abstract

Comparative chromosome painting with individual human chromosome-specific libraries (CSLs) on cattle metaphase chromosomes delineated 46 homologous chromosomal segments between the two species. Continuous arrangement of these segments on individual cattle chromosomes demonstrates a nearly complete coverage of the bovine karyotype and shows physical boundaries of bovine chromosomal segments homologous to individual human chromosomes. Alignment of the available comparative gene mapping data with the homologous segments strongly supports the detected gross homologies between the karyotypes of the two species. In addition to cattle, four human CSLs were hybridized to sheep metaphase chromosomes also, to further verify the known karyotype homology within the Bovidae. Besides its application to karyotype evolution research, the comparative knowledge provides for rapid expansion of the much needed Type I locus-based bovine gene map.

MeSH Terms
Animals Cattle/genetics Chromosome Banding Chromosome Mapping/methods Female Genome Genome, Human Humans In Situ Hybridization, Fluorescence Karyotyping Male Species Specificity
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Chowdhary B P
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, S-750 07 Uppsala, Sweden.
Frönicke L
Gustavsson I
Scherthan H
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Article Info
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
Abbr.
Mamm Genome
ISSN
0938-8990
DOI
10.1007/s003359900086
Published
1996-04-00
Pages
297-302
Language
English
Region
United States
NLM ID
9100916
Subset
IM
External Links
PubMed source DOI: 10.1007/s003359900086 View journal details
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