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PMID: 8661717 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A class of highly polymorphic tetranucleotide repeats for canine genetic mapping.

Mammalian genome : official journal of the International Mammalian Genome Society ·Vol. 7 ·No. 5 ·1996-05-00 ·Pages 359-62

Francisco LV, Langston AA, Mellersh CS, Neal CL, Ostrander EA

Abstract

We have identified and characterized a new class of polymorphic markers for the canine genome from a simple tetranucleotide repeat sequence, (GAAA)n. Genetic markers derived from this repeat are highly polymorphic compared with other canine microsatellites, yet are stable enough to be useful for following Mendelian inheritance in multigeneration pedigrees. We show further that (GAAA)n repeats are distributed throughout the canine genome and occur with sufficient frequency to be useful in the development of a framework map of the canine genome.

MeSH Terms
Animals Base Sequence Chromosome Mapping/veterinary Cosmids Dogs/genetics Female Genetic Markers Genome Male Microsatellite Repeats Molecular Sequence Data Pedigree Polymerase Chain Reaction
Chemicals
Genetic Markers
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Francisco L V
Program in Transplantation Biology, Clinical Research Division, M318, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington 98104, USA.
Langston A A
Mellersh C S
Neal C L
Ostrander E A
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Article Info
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
Abbr.
Mamm Genome
ISSN
0938-8990
DOI
10.1007/s003359900104
Published
1996-05-00
Pages
359-62
Language
English
Region
United States
NLM ID
9100916
Subset
IM
Grants
NCI NIH HHS · CA18105-20 · United States
NICHD NIH HHS · K11-HD00936 · United States
Databases
GENBANK
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External Links
PubMed source DOI: 10.1007/s003359900104 View journal details
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