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PMID: 8675700 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors.

The Journal of clinical investigation ·Vol. 97 ·No. 12 ·1996-06-15 ·Pages 2872-7

Liang TJ, Reid AE, Xavier R, Cardiff RD, Wang TC

Abstract

Receptor tyrosine kinases are important in cell signal transduction and proliferation. Abnormal expression of tyrosine kinases often leads to malignant transformation. C-met is a tyrosine kinase receptor and its ligand is hepatocyte growth factor (HGF). HGF/c-met plays diverse role in regulation of cell growth, shape and movement. Constitutively activated met, such as tpr-met, is a potent oncogene in vitro, but its carcinogenic role in vivo remains unclear. Our study demonstrates that expression of tpr-met leads to development of mammary tumors and other malignancies in transgenic mice, and suggests that deregulated met expression may be involved in mammary carcinogenesis.

MeSH Terms

Animals Base Sequence Female Hyperplasia Mammary Glands, Animal/pathology Mammary Neoplasms, Experimental/etiology Mice Mice, Transgenic Molecular Sequence Data Proto-Oncogene Proteins c-met Proto-Oncogenes Receptor Protein-Tyrosine Kinases/genetics

Chemicals

Proto-Oncogene Proteins c-met Receptor Protein-Tyrosine Kinases

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Liang T J

Department of Medicine, Massachusetts General Hospital, Boston 02114, USA. [email protected]

Reid A E

Xavier R

Cardiff R D

Wang T C

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Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI118744

[email protected]

Published

1996-06-15

Pages

2872-7

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC507382

Subset

External Links

PubMed source DOI: 10.1172/JCI118744 PMC Full Text View journal details

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Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors.

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