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PMID: 8677746 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Expression and signal transduction of the FLT3 tyrosine kinase receptor.

Acta haematologica ·Vol. 95 ·No. 3-4 ·1996-00-00 ·Pages 218-23

Rosnet O, Bühring HJ, deLapeyrière O, Beslu N, Lavagna C, Marchetto S, Rappold I, Drexler HG, Birg F, Rottapel R, Hannum C, Dubreuil P, Birnbaum D

Abstract

FLT3 is a receptor tyrosine kinase of 130-55 kDa expressed on normal bone marrow stem and early progenitor cells and on leukemic blasts from patients with acute leukemias. The FLT3 ligand, FL, is a new cytokine which acts on hematopoietic progenitors in synergy with other cytokines. FLT3 transduces FL-mediated signal through interaction with a number of cytoplasmic substrates.

MeSH Terms
Acute Disease Animals Bone Marrow/metabolism Bone Marrow Cells Evolution, Molecular Gene Expression Hematopoietic Stem Cells/metabolism Humans Leukemia/metabolism Membrane Proteins/metabolism Mice Phosphorylation Proto-Oncogene Proteins/genetics,metabolism Receptor Protein-Tyrosine Kinases/genetics,metabolism Receptors, Cell Surface/metabolism Signal Transduction fms-Like Tyrosine Kinase 3
Chemicals
Membrane Proteins Proto-Oncogene Proteins Receptors, Cell Surface flt3 ligand protein FLT3 protein, human Flt3 protein, mouse Receptor Protein-Tyrosine Kinases fms-Like Tyrosine Kinase 3
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Rosnet O
Laboratory of Molecular Oncology, U.119 INSERM, Marseille, France.
Bühring H J
deLapeyrière O
Beslu N
Lavagna C
Marchetto S
Rappold I
Drexler H G
Birg F
Rottapel R
Hannum C
Dubreuil P
Birnbaum D
Article Info
Journal
Acta haematologica
Abbr.
Acta Haematol
ISSN
0001-5792
DOI
10.1159/000203881
Published
1996-00-00
Pages
218-23
Language
English
Region
Switzerland
NLM ID
0141053
Subset
IM
External Links
PubMed source DOI: 10.1159/000203881 View journal details
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