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PMID: 8691145 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.

The Journal of experimental medicine ·Vol. 184 ·No. 1 ·1996-07-01 ·Pages 289-93

He YW, Malek TR

Abstract

Mice that lack a functional gamma c subunit of the receptors for interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 display profound defects in lymphoid development. The IL-7/IL-7R system represents a critical interaction for conventional T and B cell development. In this report, the role of IL-7R alpha in the development of lymphoid lineages other than conventional T and B cells was examined. We demonstrate that gamma delta + T cells were absent in IL-7R alpha-deficient mice, whereas the development and function of natural killer cells were normal. Thus, IL-7R alpha function is required for the development of gamma delta + T cells but not natural killer cells.

MeSH Terms
Animals Antigens, CD/physiology Cell Differentiation Flow Cytometry Killer Cells, Natural/cytology,immunology Mice Mice, Inbred C57BL Mice, Knockout Receptors, Antigen, T-Cell, gamma-delta/metabolism Receptors, Interleukin/physiology Receptors, Interleukin-7 Spleen/cytology T-Lymphocyte Subsets/cytology,immunology Thymus Gland/cytology
Chemicals
Antigens, CD Receptors, Antigen, T-Cell, gamma-delta Receptors, Interleukin Receptors, Interleukin-7
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
He Y W
Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101, USA.
Malek T R
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.184.1.289
Published
1996-07-01
Pages
289-93
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2192680
Subset
IM
Grants
NCI NIH HHS · R01-CA45957 · United States
External Links
PubMed source DOI: 10.1084/jem.184.1.289 PMC Full Text View journal details
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